Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Telmisartan
Drug ID BADD_D02147
Description Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure. Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.
Indications and Usage Used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart failure (only in patients who cannot tolerate ACE inhibitors).
Marketing Status Prescription
ATC Code C09CA07
DrugBank ID DB00966
KEGG ID D00627
MeSH ID D000077333
PubChem ID 65999
TTD Drug ID D0N6RF
NDC Product Code 68554-0049; 43547-283; 67877-484; 65862-868; 71335-0875; 65162-292; 72241-015; 65404-007; 62512-0040; 53104-7624; 65862-867; 46708-610; 71335-1723; 62332-088; 42571-226; 0378-2921; 62332-089; 62332-087; 65162-291; 65372-1146; 71209-049; 52562-009; 68462-199; 65162-293; 53746-291; 43547-284; 55545-0701; 72241-016; 0781-5374; 45865-836; 0597-0041; 70518-2572; 31722-803; 71335-1841; 13668-156; 42571-228; 57451-1206; 0781-5378; 53746-292; 12666-0010; 68071-2591; 50090-5489; 71052-679; 63629-5682; 43547-285; 62331-032; 67877-483; 71335-1428; 55111-095; 0378-2922; 71209-051; 72761-021; 72606-507; 50090-5490; 31722-804; 50370-0015; 67877-482; 68382-471; 52286-0024; 50090-5492; 68071-4937; 68382-473; 65862-869; 68462-200; 64552-4026; 31722-802; 65862-727; 68462-201; 0597-0039; 0378-2920; 65841-806; 68071-5178; 72606-506; 46708-864; 42291-792; 42291-791; 72969-100; 53746-293; 65841-805; 70518-3300; 13668-158; 65015-845; 13668-157; 63187-951; 68382-472; 46708-609; 64220-124; 72241-017; 71209-050; 42291-790; 0781-5372; 42571-227; 65841-804; 46708-608; 63629-7230; 17511-126; 72606-508; 0597-0040; 66039-895
Synonyms Telmisartan | 4'-((1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid | Pritor | BIBR 277 | BIBR-277 | Micardis
Chemical Information
Molecular Formula C33H30N4O2
CAS Registry Number 144701-48-4
SMILES CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)O)C=C(C=C2C)C5=NC6=CC=CC=C6N5C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood bilirubin increased13.03.01.0080.002560%
Blood cholesterol increased13.12.01.002--
Blood creatine phosphokinase increased13.04.01.0010.003199%
Blood creatinine increased13.13.01.0040.002560%
Blood pressure decreased13.14.03.0020.005759%Not Available
Blood pressure increased13.14.03.0050.012158%Not Available
Blood pressure systolic decreased13.14.03.0070.001280%Not Available
Blood pressure systolic increased13.14.03.0060.001920%Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.004--Not Available
Bradycardia02.03.02.0020.005119%Not Available
Breast cancer21.05.01.003; 16.10.01.0010.001280%Not Available
Bronchitis22.07.01.001; 11.01.09.0010.001280%
Bronchospasm22.03.01.004; 10.01.03.012--
Burning sensation17.02.06.001; 08.01.09.0290.001920%Not Available
Bursitis15.04.01.001--Not Available
C-reactive protein increased13.09.01.0070.001920%Not Available
Cardiac failure02.05.01.0010.001335%
Cardiac failure congestive02.05.01.002--Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Cataract06.06.01.0010.001280%
Cerebral haemorrhage17.08.01.003; 24.07.04.0010.001002%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.002560%Not Available
Cerebrovascular accident17.08.01.007; 24.03.05.0010.007039%
Cerebrovascular disorder24.03.05.002; 17.08.02.002--Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.0030.003199%Not Available
Chills15.05.03.016; 08.01.09.0010.002560%
Cholelithiasis09.03.01.0020.001920%Not Available
Chronic obstructive pulmonary disease22.03.01.0070.001280%Not Available
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