Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Telmisartan
Drug ID BADD_D02147
Description Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure. Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.
Indications and Usage Used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart failure (only in patients who cannot tolerate ACE inhibitors).
Marketing Status Prescription
ATC Code C09CA07
DrugBank ID DB00966
KEGG ID D00627
MeSH ID D000077333
PubChem ID 65999
TTD Drug ID D0N6RF
NDC Product Code 68554-0049; 43547-283; 67877-484; 65862-868; 71335-0875; 65162-292; 72241-015; 65404-007; 62512-0040; 53104-7624; 65862-867; 46708-610; 71335-1723; 62332-088; 42571-226; 0378-2921; 62332-089; 62332-087; 65162-291; 65372-1146; 71209-049; 52562-009; 68462-199; 65162-293; 53746-291; 43547-284; 55545-0701; 72241-016; 0781-5374; 45865-836; 0597-0041; 70518-2572; 31722-803; 71335-1841; 13668-156; 42571-228; 57451-1206; 0781-5378; 53746-292; 12666-0010; 68071-2591; 50090-5489; 71052-679; 63629-5682; 43547-285; 62331-032; 67877-483; 71335-1428; 55111-095; 0378-2922; 71209-051; 72761-021; 72606-507; 50090-5490; 31722-804; 50370-0015; 67877-482; 68382-471; 52286-0024; 50090-5492; 68071-4937; 68382-473; 65862-869; 68462-200; 64552-4026; 31722-802; 65862-727; 68462-201; 0597-0039; 0378-2920; 65841-806; 68071-5178; 72606-506; 46708-864; 42291-792; 42291-791; 72969-100; 53746-293; 65841-805; 70518-3300; 13668-158; 65015-845; 13668-157; 63187-951; 68382-472; 46708-609; 64220-124; 72241-017; 71209-050; 42291-790; 0781-5372; 42571-227; 65841-804; 46708-608; 63629-7230; 17511-126; 72606-508; 0597-0040; 66039-895
Synonyms Telmisartan | 4'-((1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid | Pritor | BIBR 277 | BIBR-277 | Micardis
Chemical Information
Molecular Formula C33H30N4O2
CAS Registry Number 144701-48-4
SMILES CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)O)C=C(C=C2C)C5=NC6=CC=CC=C6N5C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.003839%Not Available
Abdominal distension07.01.04.0010.002560%
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.0030.005119%
Abnormal faeces07.01.03.0010.001280%Not Available
Abortion spontaneous18.01.04.001--Not Available
Abscess11.01.08.001--Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.0010.002560%Not Available
Aggression19.05.01.0010.001280%Not Available
Agranulocytosis01.02.03.0010.001280%Not Available
Altered state of consciousness17.02.04.001; 19.07.01.0030.003199%Not Available
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactic shock24.06.02.004; 10.01.07.0020.001920%Not Available
Aneurysm24.02.01.0010.001280%Not Available
Angina pectoris24.04.04.002; 02.02.02.0020.001920%
Angioedema23.04.01.001; 10.01.05.0090.004479%Not Available
Anuria20.01.03.0020.001920%Not Available
Anxiety19.06.02.0020.005759%
Arrhythmia02.03.02.0010.003199%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Asphyxia22.02.02.001; 12.01.08.0110.000334%Not Available
Asthenia08.01.01.0010.008959%Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Atrial fibrillation02.03.03.0020.003839%
Atrioventricular block complete02.03.01.0030.001920%
Back pain15.03.04.005--
Bladder pain20.02.02.001--Not Available
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