| Pharmaceutical Information |
| Drug Name |
Telithromycin |
| Drug ID |
BADD_D02146 |
| Description |
Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis. Telithromycin binds to the 50S subunit of the 70S bacterial ribosome and blocks further peptide elongation. Binding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. It is used to treat mild to moderate respiratory infections. |
| Indications and Usage |
For the treatment of Pneumococcal infection, acute sinusitis, acute bacterial tonsillitis, acute bronchitis and bronchiolitis, lower respiratory tract infection and lobar (pneumococcal) pneumonia. |
| Marketing Status |
Discontinued |
| ATC Code |
J01FA15 |
| DrugBank ID |
DB00976
|
| KEGG ID |
D01078
|
| MeSH ID |
C106791
|
| PubChem ID |
3002190
|
| TTD Drug ID |
D09HNR
|
| NDC Product Code |
Not Available |
| Synonyms |
telithromycin | Ketek | RU 66647 | RU-66647 | HMR 3647 | HMR3647 | HMR-3647 |
|
| Chemical Information |
| Molecular Formula |
C43H65N5O10 |
| CAS Registry Number |
191114-48-4 |
| SMILES |
CCC1C2(C(C(C(=O)C(CC(C(C(C(=O)C(C(=O)O1)C)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)N(C
(=O)O2)CCCCN4C=C(N=C4)C5=CN=CC=C5)C |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
|
