Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tapentadol hydrochloride
Drug ID BADD_D02116
Description Opioid analgesic for treatment of moderate to severe pain. FDA approved on Nov 20, 2008.
Indications and Usage The immediate-release formulation of tapentadol is indicated for the relief of moderate to severe acute pain. The long-acting formulation serves as a continuous, around-the-clock analgesic that is indicated for the relief of moderate to severe chronic pain or neuropathic pain associated with diabetic peripheral neuropathy.
Marketing Status Prescription
ATC Code N02AX06
DrugBank ID DB06204
KEGG ID D10199
MeSH ID D000077432
PubChem ID 9838021
TTD Drug ID D0K4MH
NDC Product Code 24510-058; 65267-101; 24510-116; 17180-9780; 24510-050; 24510-232; 24510-100; 55700-796; 24510-174; 24510-291; 24510-075; 55700-797
Synonyms Tapentadol | 3-((1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl)phenol | Nucynta | Tapentadol Hydrochloride
Chemical Information
Molecular Formula C14H24ClNO
CAS Registry Number 175591-09-0
SMILES CCC(C1=CC(=CC=C1)O)C(C)CN(C)C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lung disorder22.02.07.001--Not Available
Memory impairment17.03.02.003; 19.20.01.003--
Menopausal symptoms21.02.02.002--Not Available
Mental disability26.01.01.001--Not Available
Muscle contractions involuntary17.05.03.001; 15.05.03.008--Not Available
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Nightmare19.02.03.003--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Osteoarthritis15.01.04.001--Not Available
Oxygen saturation decreased13.02.01.004--Not Available
Palpitations02.01.02.003--
Panic attack19.06.04.001--Not Available
Paraesthesia17.02.06.005--
Pollakiuria20.02.02.007--
Presyncope24.06.02.010; 17.02.05.009; 02.01.02.007--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Restlessness19.11.02.002; 17.02.05.021--
Sedation17.02.04.005--Not Available
Seizure17.12.03.001--
Serotonin syndrome17.05.02.004; 15.05.04.016; 12.03.01.041--Not Available
Sexual dysfunction19.08.05.002; 21.03.02.003--Not Available
Shock24.06.02.002--Not Available
Skin disorder23.03.03.007--Not Available
Somnolence17.02.04.006; 19.02.05.003--
Suicidal ideation19.12.01.003--
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