Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tamoxifen
Drug ID BADD_D02111
Description Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment for these types of cancers as patients generally have better survival, side effect profiles, and compliance with [anastrozole].[A1026] Tamoxifen was granted FDA approval on 30 December 1977.[L7799]
Indications and Usage Tamoxifen is indicated for the treatment of metastatic breast cancer in women and men and ductal carcinoma in Situ.
Marketing Status Prescription; Discontinued
ATC Code L02BA01
DrugBank ID DB00675
KEGG ID D08559
MeSH ID D013629
PubChem ID 2733526
TTD Drug ID D07KSG
NDC Product Code Not Available
Synonyms Tamoxifen | ICI-47699 | ICI 47699 | ICI47699 | Nolvadex | Novaldex | Tamoxifen Citrate | Citrate, Tamoxifen | Tomaxithen | Zitazonium | ICI-46474 | ICI 46474 | ICI46474 | ICI-46,474 | ICI 46,474 | ICI46,474 | Soltamox
Chemical Information
Molecular Formula C26H29NO
CAS Registry Number 10540-29-1
SMILES CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatocellular injury09.01.07.008--Not Available
Hypercalcaemia05.04.01.002; 14.04.01.003--
Hyperhidrosis23.02.03.004; 08.01.03.0280.002047%
Hyperplasia08.03.04.008--Not Available
Hypersensitivity10.01.03.003--
Influenza like illness08.01.03.0100.001024%
Insomnia19.02.01.002; 17.15.03.0020.002559%
Interstitial lung disease22.01.02.003; 10.02.01.033--Not Available
Keratopathy06.06.03.0070.001024%Not Available
Malaise08.01.01.0030.002047%
Memory impairment19.20.01.003; 17.03.02.0030.001024%
Menopausal symptoms21.02.02.002--Not Available
Menstruation irregular21.01.01.005; 05.05.01.008--
Migraine17.14.02.001; 24.03.05.0030.001024%Not Available
Mood altered19.04.02.0070.002559%Not Available
Muscle spasms15.05.03.0040.001024%
Myalgia15.05.02.0010.001535%
Nausea07.01.07.0010.002047%
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Optic neuritis17.04.05.001; 10.04.10.002; 06.04.08.002--Not Available
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.0050.001024%
Pemphigoid23.03.01.004; 10.04.02.002--Not Available
Porphyria non-acute03.08.01.004; 23.03.01.012; 14.14.01.004; 09.01.10.003--Not Available
Pruritus23.03.12.0010.001024%
Rash23.03.13.0010.001535%Not Available
Sarcoma uterus21.07.02.005; 16.33.01.001--Not Available
Stevens-Johnson syndrome23.03.01.007; 11.07.01.005; 12.03.01.014; 10.01.03.020--
Swelling08.01.03.015--Not Available
Thrombosis24.01.01.006--Not Available
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