Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sulfasalazine
Drug ID BADD_D02093
Description A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Indications and Usage For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.
Marketing Status Prescription; Discontinued
ATC Code A07EC01
DrugBank ID DB00795
KEGG ID D00448
MeSH ID D012460
PubChem ID 5339
TTD Drug ID D02ZTJ
NDC Product Code 68071-4215; 23155-019; 70518-1829; 50090-0086; 49964-0018; 43353-495; 63629-5688; 70518-0185; 51927-0054; 51927-0081; 0591-0796; 0013-0101; 59762-0104; 38779-0176; 0013-0102; 50268-730; 59116-0632; 62705-0222; 62991-2704; 57294-021; 59116-0631; 71610-577; 59762-5000; 59116-0633; 59116-0630; 62135-960; 51552-1044; 50090-2013; 49452-7523; 68022-7065; 70518-2342
Synonyms Sulfasalazine | Salicylazosulfapyridine | Sulphasalazine | Salazosulfapyridine | Pyralin EN | Azulfadine | Azulfidine EN | Azulfidine | Asulfidine | Colo-Pleon | Colo Pleon | Pleon | Ulcol | Sulfasalazin medac | Sulfasalazin-Heyl | Sulfasalazin Heyl | Sulfasalazine FNA | Ucine | Salazopyrin | ratio-Sulfasalazine | ratio Sulfasalazine
Chemical Information
Molecular Formula C18H14N4O5S
CAS Registry Number 599-79-1
SMILES C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Leukopenias NECCytochrome P450 1A2P05177Not Available11600468; 11856081; 11600469
VasculitisMyeloperoxidaseP05164T234717913504; 7913503; 8102951; 7914458; 8624621; 7869327; 7835022; 8095074; 8624617
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Arthritis15.01.01.0010.002763%
Arthropathy15.01.01.0030.002072%Not Available
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.002072%
Aspartate aminotransferase increased13.03.01.0060.003454%
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.0100.002072%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atrial fibrillation02.03.03.002--
Azoospermia21.03.03.001--
Back pain15.03.04.005--
Basal cell carcinoma23.08.02.001; 16.03.02.0010.001382%Not Available
Blister23.03.01.001; 12.01.06.0020.002763%Not Available
Blood bilirubin increased13.03.01.008--
Blood creatinine increased13.13.01.004--
Blood lactate dehydrogenase increased13.04.02.002--
Blood pressure fluctuation24.06.01.0020.001382%Not Available
Blood pressure increased13.14.03.005--Not Available
Body temperature increased13.15.01.0010.002763%Not Available
C-reactive protein increased13.09.01.0070.008289%Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardiac murmur13.14.01.0010.001382%Not Available
Cardiac tamponade02.06.01.0010.001382%
Cardiogenic shock24.06.02.006; 02.05.01.0030.000360%Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.0010.003454%Not Available
Cataract06.06.01.0010.004145%
Cauda equina syndrome17.10.01.001--Not Available
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
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