Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Sulfasalazine
Drug ID BADD_D02093
Description A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Indications and Usage For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.
Marketing Status approved
ATC Code A07EC01
DrugBank ID DB00795
KEGG ID D00448
MeSH ID D012460
PubChem ID 5339
TTD Drug ID D02ZTJ
NDC Product Code 63629-5688; 49452-7523; 59116-0631; 0093-3234; 70518-0185; 51552-1044; 51927-0081; 50090-2013; 59762-5000; 62135-960; 70518-1829; 70518-3732; 0013-0102; 71610-577; 62705-0222; 62991-2704; 59762-0104; 70518-2342; 71610-706; 49964-0018; 57294-021; 50090-0086; 51927-0054; 59116-0632; 0591-0796; 23155-019; 0013-0101; 63629-9715; 38779-0176; 59116-0630; 59116-0633; 68022-7065
UNII 3XC8GUZ6CB
Synonyms Sulfasalazine | Salicylazosulfapyridine | Sulphasalazine | Salazosulfapyridine | Pyralin EN | Azulfadine | Azulfidine EN | Azulfidine | Asulfidine | Colo-Pleon | Colo Pleon | Pleon | Ulcol | Sulfasalazin medac | Sulfasalazin-Heyl | Sulfasalazin Heyl | Sulfasalazine FNA | Ucine | Salazopyrin | ratio-Sulfasalazine | ratio Sulfasalazine
Chemical Information
Molecular Formula C18H14N4O5S
CAS Registry Number 599-79-1
SMILES C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.024246%Not Available
Abdominal pain07.01.05.0020.006637%
Abdominal pain upper07.01.05.0030.005334%
Abnormal faeces07.01.03.001--Not Available
Acute febrile neutrophilic dermatosis23.03.03.033; 01.02.01.0060.000455%Not Available
Acute hepatic failure09.01.03.0010.000758%Not Available
Agranulocytosis01.02.03.0010.001212%Not Available
Alanine aminotransferase increased13.03.04.005--
Alopecia23.02.02.001--
Alveolitis22.01.01.0010.000909%Not Available
Anaemia01.03.02.001--
Anaemia Heinz body01.04.01.001--Not Available
Anaemia macrocytic14.12.01.002; 01.03.02.002--Not Available
Anaemia megaloblastic14.12.01.003; 01.03.02.003--Not Available
Anal fistula07.11.05.0020.000303%
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Anaphylactoid reaction10.01.07.003; 24.06.03.007--Not Available
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Ankylosing spondylitis15.01.09.001; 10.04.04.0040.002394%Not Available
Anuria20.01.03.002--Not Available
Aphthous ulcer07.05.06.002--Not Available
Aplasia pure red cell10.02.01.003; 01.03.03.0010.000455%Not Available
Aplastic anaemia01.03.03.002--Not Available
Arthralgia15.01.02.0010.015093%
Arthritis15.01.01.0010.000909%
Arthropathy15.01.01.0030.001637%Not Available
Aspartate aminotransferase increased13.03.04.011--
Ataxia17.02.02.001; 08.01.02.004--
Azoospermia21.03.03.001--
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ADReCS-Target
Drug Name ADR Term Target
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