Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sulfamethoxazole
Drug ID BADD_D02091
Description Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria.[L11830] It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps in the biosynthesis of nucleic acids and proteins which are necessary for bacterial growth and division, and using them in conjunction helps to slow the development of bacterial resistance.[L11830] In this combination, sulfamethoxazole is useful for the treatment of a variety of bacterial infections, including those of the urinary, respiratory, and gastrointestinal tracts.
Indications and Usage For the treatment bacterial infections causing bronchitis, prostatitis and urinary tract infections.
Marketing Status Discontinued
ATC Code J01EC01
DrugBank ID DB01015
KEGG ID D00447
MeSH ID D013420
PubChem ID 5329
TTD Drug ID D0R9OH
NDC Product Code 66326-216; 64374-002; 62991-3046; 49452-7505; 38779-0261; 38779-2793; 66249-0456; 51927-4515
Synonyms Sulfamethoxazole | Sulphamethoxazole | Sulfamethylisoxazole | Sulfisomezole | Gantanol
Chemical Information
Molecular Formula C10H11N3O3S
CAS Registry Number 723-46-6
SMILES CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
AgranulocytosisAlbuminP02768T630687902244; 1664258; 8385460; 2856515; 1650217; 9022075; 1324677; 12060654; 11440179; 9243259; 16214851
AgranulocytosisMyeloperoxidaseP05164T234717902244; 1664258; 8385460; 2856515; 1650217; 9022075; 1324677; 12060654; 11440179; 9243259; 16214851
GranulocytopeniaArylamine N-acetyltransferase 2P11245Not Available8614026; 11399123; 7563219; 15167686
Liver injuryArylamine N-acetyltransferase 2P11245Not Available8614026; 11399123; 7563219; 15167686
Lupus erythematosus (incl subtypes)MyeloperoxidaseP05164T234717902244; 1664258; 8385460; 2856515; 1650217; 9022075; 1324677; 12060654; 11440179; 9243259; 16214851
Lupus erythematosus (incl subtypes)AlbuminP02768T630687902244; 1664258; 8385460; 2856515; 1650217; 9022075; 1324677; 12060654; 11440179; 9243259; 16214851
RashArylamine N-acetyltransferase 2P11245Not Available8614026; 11399123; 7563219; 15167686
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001--Not Available
Anaemia megaloblastic14.12.01.003; 01.03.02.003--Not Available
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anuria20.01.03.002--Not Available
Apathy19.04.04.002--Not Available
Aplastic anaemia01.03.03.002--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Body temperature increased13.15.01.001--Not Available
Chills15.05.03.016; 08.01.09.001--
Cough22.02.03.001--
Crystalluria20.02.01.003--Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.001--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Eosinophilia01.02.04.001--
Eosinophilic myocarditis01.02.04.007; 02.04.03.002--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.002--
Flat affect19.04.01.004--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Glossitis07.14.01.001--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Hallucination19.10.02.002--
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