Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sufentanil citrate
Drug ID BADD_D02083
Description Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to warrant the use of an opioid analgesic in certified medically supervised healthcare settings, including hospitals, surgical centers, and emergency departments [L4717]. Consideration may be made in the future for the use of the sublingual form in the US military in cases where analgesia is required immediately [L4718]. The sublingual form, manufactured by AcelRx Pharmaceuticals, Inc. (AcelRx), was approved on November 2, 2018 [L4717]. This route of administration is intended to be a simple, effective, non-invasive analgesic option to enable healthcare professionals to rapidly manage acute pain without difficult intravenous or epidural administration [L4717], [A39633].
Indications and Usage Used as an analgesic adjunct in anesthesia and as a primary anesthetic drug in procedures requiring assisted ventilation and in the relief of pain.
Marketing Status Prescription; Discontinued
ATC Code N01AH03
DrugBank ID DB00708
KEGG ID D00845
MeSH ID D017409
PubChem ID 65494
TTD Drug ID D0D8DD
NDC Product Code 38779-1968; 0406-0678; 0409-3382; 0641-6112; 82393-121; 0641-6111; 17478-050; 0641-6110; 81371-3001; 49452-7247; 51552-0889; 49812-0021; 51927-3213; 0406-0672; 63275-6200
Synonyms Sufentanil | Sulfentanyl | Sulfentanil | Sufenta | Sufentanil-Ratiopharm | Sufentanil Ratiopharm | SufentanilRatiopharm | Sufentanil Curasan | Curasan, Sufentanil | Sufentanil-Hameln | Sufentanil Hameln | SufentanilHameln | R-30730 | R 30730 | R30730 | Sufentanil Citrate | Citrate, Sufentanil
Chemical Information
Molecular Formula C28H38N2O9S
CAS Registry Number 60561-17-3
SMILES CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC3=CC=CS3)COC.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Apnoea22.02.01.001--
Arrhythmia02.03.02.001--Not Available
Bradycardia02.03.02.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac arrest02.03.04.001--
Chills15.05.03.016; 08.01.09.001--
Dyskinesia17.01.02.006--
Erythema23.03.06.001--Not Available
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Hypotonia15.05.04.008; 17.05.02.002--Not Available
Nausea07.01.07.001--
Pruritus23.03.12.001--
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Tachycardia02.03.02.007--Not Available
Vomiting07.01.07.003--
Postoperative respiratory distress22.02.06.006; 12.02.07.001--Not Available
Urinary tract obstruction20.08.01.004--
Chest wall mass15.03.01.013--Not Available
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