Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Streptozocin
Drug ID BADD_D02073
Description An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Indications and Usage For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).
Marketing Status Prescription
ATC Code L01AD04
DrugBank ID DB00428
KEGG ID D05932
MeSH ID D013311
PubChem ID 29327
TTD Drug ID D0I8RR
NDC Product Code 0703-4636
Synonyms Streptozocin | Streptozotocine | 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose | Streptozotocin | Zanosar
Chemical Information
Molecular Formula C8H15N3O7
CAS Registry Number 18883-66-4
SMILES CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1Q9UHR4Not Available2332119; 7523453; 2551653; 2537893; 1661694; 1331176; 16358398; 2227134; 10391142; 10449437; 3548422; 2838251; 12882908; 2180315; 2820811; 10871198; 8127894; 1324860
Diabetes mellitusPolyunsaturated fatty acid lipoxygenase ALOX15P39654Not Available25598081
HyperglycaemiaMicrotubule-associated proteins 1A/1B light chain 3BQ62625Not Available25725139
HyperglycaemiaEndoplasmic reticulum chaperone BiPP06761Not Available25725139
HyperinsulinismBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1Q9UHR4Not Available2332119; 7523453; 2551653; 2537893; 1661694; 1331176; 16358398; 2227134; 10391142; 10449437; 3548422; 2838251; 12882908; 2180315; 2820811; 10871198; 8127894; 1324860
HyperphagiaMicrotubule-associated proteins 1A/1B light chain 3BQ62625Not Available25725139
HyperphagiaEndoplasmic reticulum chaperone BiPP06761Not Available25725139
NeurotoxicityAcetylcholinesteraseP21836Not Available25823512
NeurotoxicityCaspase-3P55213Not Available25823512
PolydipsiaEndoplasmic reticulum chaperone BiPP06761Not Available25725139
PolydipsiaMicrotubule-associated proteins 1A/1B light chain 3BQ62625Not Available25725139
Vascular anomalies congenital NECEndoplasmic reticulum chaperone BiPP06761Not Available25725139
Vascular anomalies congenital NECMicrotubule-associated proteins 1A/1B light chain 3BQ62625Not Available25725139
Weight decreasedEndoplasmic reticulum chaperone BiPP06761Not Available25725139
Weight decreasedMicrotubule-associated proteins 1A/1B light chain 3BQ62625Not Available25725139
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Aggression19.05.01.001--Not Available
Aminoaciduria14.14.04.003; 03.08.04.003; 20.02.01.024--Not Available
Anaemia01.03.02.001--
Anuria20.01.03.002--Not Available
Aspartate aminotransferase increased13.03.01.006--
Azotaemia20.01.01.001--Not Available
Blood bilirubin increased13.03.01.008--
Blood lactate dehydrogenase increased13.04.02.002--
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Death08.04.01.001--
Diarrhoea07.02.01.001--
Eosinophilia01.02.04.001--
Erythema23.03.06.001--Not Available
Extravasation08.01.03.008--Not Available
Febrile neutropenia08.05.02.004; 01.02.03.002--
Feeling abnormal08.01.09.014--Not Available
Glucose tolerance impaired14.06.02.001; 05.06.02.001--
Glycosuria20.02.01.005--
Haematocrit decreased13.01.05.001--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Hyperchloraemia14.05.08.001--Not Available
Hypoalbuminaemia14.10.01.002; 09.01.02.003--
Hypocalcaemia14.04.01.004--
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypokalaemia14.05.03.002--
Hypophosphataemia14.04.03.001--
Injection site pain12.07.03.011; 08.02.03.010--Not Available
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