Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Streptomycin
Drug ID BADD_D02071
Description Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activity.[A233325,A232294] Although streptomycin was the first antibiotic determined to be effective against mycobacterium tuberculosis, it has fallen out of favor due to resistance and is now primarily used as adjunctive treatment in cases of multi-drug resistant tuberculosis.[A233325]
Indications and Usage For the treatment of tuberculosis. May also be used in combination with other drugs to treat tularemia (Francisella tularensis), plague (Yersia pestis), severe M. avium complex, brucellosis, and enterococcal endocarditis (e.g. E. faecalis, E. faecium).
Marketing Status Prescription; Discontinued
ATC Code A07AA04; J01GA01
DrugBank ID DB01082
KEGG ID D08531
MeSH ID D013307
PubChem ID 19649
TTD Drug ID D0N0EQ
NDC Product Code 39822-0706
Synonyms Streptomycin | Streptomycine Panpharma | Streptomycin Grünenthal | Estreptomicina CEPA | Strepto-Hefa | Strepto Hefa | Estreptomicina Clariana | Estreptomicina Normon | Strepto-Fatol | Strepto Fatol | Streptomycin Sulfate | Streptomycin Sulfate (2:3) Salt | Streptomycin Sulphate
Chemical Information
Molecular Formula C21H39N7O12
CAS Registry Number 57-92-1
SMILES CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alkalosis14.01.02.0010.000408%
Amblyopia06.02.01.001--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Aplastic anaemia01.03.03.0020.000159%Not Available
Azotaemia20.01.01.001--Not Available
Deafness neurosensory17.04.07.001; 04.02.01.002--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.000408%
Drug hypersensitivity10.01.01.0010.001630%Not Available
Eosinophilia01.02.04.001--
Haemolytic anaemia01.06.03.002--Not Available
Hypersensitivity10.01.03.0030.001019%
Hypocalcaemia14.04.01.0040.001019%
Hypokalaemia14.05.03.0020.000611%
Leukopenia01.02.02.001--Not Available
Liver disorder09.01.08.0010.000213%Not Available
Muscle spasms15.05.03.0040.000408%
Muscular weakness17.05.03.005; 15.05.06.001--
Nausea07.01.07.001--
Nephropathy toxic20.05.03.002; 12.03.01.010--Not Available
Nephrotic syndrome20.05.01.0020.000106%
Ototoxicity12.03.01.012; 04.03.01.0040.000408%Not Available
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.0050.000408%
Pyrexia08.05.02.0030.000611%
Rash23.03.13.0010.000408%Not Available
Tetany05.04.02.003; 15.05.03.013; 14.04.01.0050.000408%Not Available
Thrombocytopenia01.08.01.002--Not Available
Urticaria23.04.02.001; 10.01.06.0010.000815%
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