Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sorbitol
Drug ID BADD_D02059
Description A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures.
Indications and Usage Used as a non-stimulant laxative via an oral suspension or enema.
Marketing Status Prescription; Discontinued
ATC Code A06AD18; A06AG07; B05CX02; V04CC01
DrugBank ID DB01638
KEGG ID D00096
MeSH ID D013012
PubChem ID 5780
TTD Drug ID D09MXS
NDC Product Code 57896-435; 51552-0216; 51552-0096; 57896-758; 50516-005; 0338-0295
Synonyms Sorbitol | Glucitol | Yal | Sorbilax | klysma Sorbit | Medevac
Chemical Information
Molecular Formula C6H14O6
CAS Registry Number 50-70-4
SMILES C(C(C(C(C(CO)O)O)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ApoptosisProtein kinase C delta typeQ05655T4486111232246; 11483859; 11477551
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acidosis14.01.03.002--
Angina pectoris24.04.04.002; 02.02.02.002--
Back pain15.03.04.005--
Blood glucose increased13.02.02.002--Not Available
Chills15.05.03.016; 08.01.09.001--
Dehydration14.05.05.001--
Diarrhoea07.02.01.001--
Dry mouth07.06.01.002--
Electrolyte imbalance14.05.01.002--Not Available
Fluid overload14.05.06.001; 02.05.04.004--Not Available
Hyperosmolar state14.05.01.005--Not Available
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Lung disorder22.02.07.001--Not Available
Nausea07.01.07.001--
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain08.01.08.004--
Polyuria20.02.03.002--Not Available
Pulmonary congestion02.05.02.002; 24.03.08.001; 22.01.03.002--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Seizure17.12.03.001--
Tachycardia02.03.02.007--Not Available
Thirst08.01.09.021; 14.03.02.007--Not Available
Urinary retention20.02.02.011--
Urticaria10.01.06.001; 23.04.02.001--
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.007--
Vitamin B12 deficiency14.12.02.004--Not Available
Vomiting07.01.07.003--
Respiratory tract congestion22.02.07.003--Not Available
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