Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sodium nitrite
Drug ID BADD_D02045
Description Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applicability towards treatments for heart attacks, brain aneurysms, pulmonary hypertension in infants, and Pseudomonas aeruginosa infections.
Indications and Usage For sequential use with sodium thiosulfate for the treatment of acute cyanide poisoning that is judged to be life-threatening [FDA Label].
Marketing Status Prescription
ATC Code V03AB08
DrugBank ID DB09112
KEGG ID D05865
MeSH ID D012977
PubChem ID 23668193
TTD Drug ID D0MA7C
NDC Product Code 64181-0041; 60267-311
Synonyms Sodium Nitrite | Nitrite, Sodium
Chemical Information
Molecular Formula NO2.Na
CAS Registry Number 7632-00-0
SMILES N(=O)[O-].[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acidosis14.01.03.002--
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Coma17.02.09.001--Not Available
Confusional state17.02.03.005; 19.13.01.001--
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Death08.04.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspnoea22.02.01.004; 02.01.03.002--
Fatigue08.01.01.002--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypoaesthesia17.02.06.023--Not Available
Hypotension24.06.03.002--
Injection site paraesthesia17.02.06.029; 12.07.03.049; 08.02.03.049--Not Available
Methaemoglobinaemia01.05.01.002--
Nausea07.01.07.001--
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Seizure17.12.03.001--
Syncope17.02.04.008; 02.01.02.008; 24.06.02.012--
Tachycardia02.03.02.007--Not Available
Tachypnoea22.02.01.014--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
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