Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sevoflurane
Drug ID BADD_D02015
Description Sevoflurane, also called fluoromethyl, is an ether inhalation anaesthetic agent used for the induction and maintenance of general anesthesia. It is a volatile, non-flammable, non-irritant, and easy-to-administer compound with a low solubility profile and blood-to-gas partition coefficient.
Indications and Usage Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.
Marketing Status Prescription
ATC Code N01AB08
DrugBank ID DB01236
KEGG ID D00547
MeSH ID D000077149
PubChem ID 5206
TTD Drug ID D0W6ZF
NDC Product Code 0074-4456; 10019-651; 0781-6160; 12164-005; 66794-015; 66794-022; 54122-4486; 10019-653; 42677-110; 66794-012; 57884-0036; 12164-009
Synonyms Sevoflurane | Fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl Ether | Fluoromethyl Hexafluoroisopropyl Ether | Sevorane | Ultane | BAX 3084
Chemical Information
Molecular Formula C4H3F7O
CAS Registry Number 28523-86-6
SMILES C(OC(C(F)(F)F)C(F)(F)F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Cognitive disorderApoptosis regulator Bcl-2P10415T3130925774088
Cognitive disorderCaspase-3P42574T5794325774088
Cognitive disorderGlycine receptor subunit alpha-1P23415T5026925774088
Cognitive disorderApoptosis regulator BAXQ07812T8925125774088
Nerve injuryGlycine receptor subunit alpha-1P23415T5026925774088
Nerve injuryApoptosis regulator Bcl-2P49950Not Available25774088
Nerve injuryCaspase-3P42574T5794325774088
Nerve injuryApoptosis regulator BAXQ07812T8925125774088
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Skin disorder23.03.03.007--Not Available
Skin odour abnormal23.03.03.0120.000788%
Somnolence19.02.05.003; 17.02.04.006--
Sputum increased22.02.03.007--Not Available
Stridor22.04.02.003--
Supraventricular extrasystoles02.03.03.011--Not Available
Supraventricular tachycardia02.03.03.0120.000788%
Swelling face23.04.01.018; 10.01.05.018--Not Available
Syncope02.01.02.008; 17.02.04.008; 24.06.02.012--
Tachycardia02.03.02.0070.004335%Not Available
Tension19.06.02.005--Not Available
Thrombocytopenia01.08.01.0020.001970%Not Available
Torsade de pointes02.03.04.0050.000788%Not Available
Urethral disorder20.07.01.002--Not Available
Urinary retention20.02.02.011--
Urinary tract disorder20.08.01.001--Not Available
Urine abnormality20.02.01.013--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Ventricular extrasystoles02.03.04.007--Not Available
Ventricular fibrillation02.03.04.0080.000411%
Ventricular tachycardia02.03.04.010--
Vomiting07.01.07.003--
Wheezing22.03.01.009--
White blood cell count abnormal13.01.06.0280.001970%Not Available
White blood cell count decreased13.01.06.0120.001970%
Tubulointerstitial nephritis20.05.02.002--Not Available
Urosepsis20.08.02.002; 11.01.11.0050.000788%Not Available
Electrocardiogram ST-T segment depression13.14.05.038--Not Available
Single umbilical artery03.07.09.001; 24.03.03.010; 18.04.14.0020.000206%Not Available
Neonatal hypoxia18.04.15.002; 22.11.02.0020.000788%Not Available
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