Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sevelamer
Drug ID BADD_D02012
Description Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel.
Indications and Usage For the control of serum phosphorus in patients with Chronic Kidney Disease (CKD) on hemodialysis.
Marketing Status Prescription; Discontinued
ATC Code V03AE02
DrugBank ID DB00658
KEGG ID D08512
MeSH ID D000069603
PubChem ID 3085017
TTD Drug ID D03MZQ
NDC Product Code Not Available
Synonyms Sevelamer | GT335-012 | GT335 012 | GT335012 | Sevelamer Hydrochloride | Hydrochloride, Sevelamer | RenaGel | Sevelamer Carbonate | Carbonate, Sevelamer
Chemical Information
Molecular Formula C6H12ClNO
CAS Registry Number 52757-95-6
SMILES C=CCN.C1C(O1)CCl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vomiting07.01.07.0030.254760%
Weight decreased13.15.01.005--
White blood cell count increased13.01.06.013--Not Available
Pneumoperitoneum07.07.01.0080.001975%Not Available
Blood phosphorus increased13.11.01.0160.002962%Not Available
Subileus07.13.01.004--Not Available
Large intestine polyp16.05.02.006; 07.20.01.0100.002962%Not Available
Gastrointestinal hypomotility07.02.02.0050.010862%Not Available
Eye pruritus06.04.05.0060.002962%Not Available
Pruritus generalised23.03.12.003--Not Available
Epigastric discomfort07.01.02.0040.001975%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Blood phosphorus abnormal13.11.01.0170.003950%Not Available
Haemorrhage24.07.01.002--Not Available
Faecaloma07.01.03.0040.001975%Not Available
Faecalith07.01.03.007--Not Available
Colon injury12.01.02.001; 07.11.01.0050.001975%Not Available
Abdominal abscess11.01.07.006; 07.19.02.0020.001975%Not Available
Cardiac disorder02.01.01.003--Not Available
Gastrointestinal injury07.11.01.006; 12.01.02.0020.001975%Not Available
Gastrointestinal motility disorder07.02.03.0010.015799%Not Available
Inflammation08.01.05.007--Not Available
Metastatic neoplasm16.16.01.0070.001975%Not Available
Cardiac valve disease02.07.02.0010.001975%Not Available
Decreased appetite08.01.09.028; 14.03.01.005--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Polyp16.02.02.005; 08.01.06.0100.001975%Not Available
Lower limb fracture12.04.01.004; 15.08.03.004--Not Available
Unevaluable event08.01.03.051--Not Available
Bowel movement irregularity07.02.03.0030.002962%Not Available
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