Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sevelamer
Drug ID BADD_D02012
Description Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel.
Indications and Usage For the control of serum phosphorus in patients with Chronic Kidney Disease (CKD) on hemodialysis.
Marketing Status Prescription; Discontinued
ATC Code V03AE02
DrugBank ID DB00658
KEGG ID D08512
MeSH ID D000069603
PubChem ID 3085017
TTD Drug ID D03MZQ
NDC Product Code Not Available
Synonyms Sevelamer | GT335-012 | GT335 012 | GT335012 | Sevelamer Hydrochloride | Hydrochloride, Sevelamer | RenaGel | Sevelamer Carbonate | Carbonate, Sevelamer
Chemical Information
Molecular Formula C6H12ClNO
CAS Registry Number 52757-95-6
SMILES C=CCN.C1C(O1)CCl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Muscle spasms15.05.03.004--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.0010.452248%
Ocular hyperaemia06.04.05.0040.013824%Not Available
Oesophageal ulcer07.04.05.0020.001975%
Pain08.01.08.004--
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Parathyroid disorder05.04.03.0010.001975%Not Available
Pemphigoid23.03.01.004; 10.04.02.002--Not Available
Peritonitis11.01.07.007; 07.19.05.0040.003950%
Pleural effusion22.05.02.002--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Productive cough22.02.03.005--
Pruritus23.03.12.0010.839325%
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Rash pruritic23.03.12.002--Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Rectal ulcer07.04.01.0020.003950%
Renal failure20.01.03.005--Not Available
Retching07.01.07.0020.002962%Not Available
Seizure17.12.03.001--
Sepsis11.01.11.003--
Somnolence17.02.04.006; 19.02.05.003--
Suicidal ideation19.12.01.003--
Tenderness08.01.08.005--Not Available
Thrombocytopenia01.08.01.002--Not Available
Ulcer08.03.06.001--Not Available
Urticaria23.04.02.001; 10.01.06.001--
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