Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Sertraline hydrochloride
Drug ID BADD_D02011
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD).[L9016] Common off-label uses for sertraline include the prevention of post stroke depression[A187078], generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope.[L5227]
Marketing Status approved
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D00825
MeSH ID D020280
PubChem ID 63009
TTD Drug ID D0K0TC
NDC Product Code 65015-821; 65862-013; 42337-201; 43063-754; 50228-467; 53002-2507; 60760-738; 0049-0050; 63629-8127; 65862-224; 68071-4494; 70518-2448; 71093-143; 72865-205; 65977-0056; 51655-173; 52427-672; 55700-948; 65862-011; 68071-4029; 71335-0415; 82982-043; 55111-968; 65862-012; 77777-108; 43063-855; 43602-980; 51655-265; 55154-4692; 60687-253; 68645-521; 68645-522; 68788-8210; 69097-835; 70010-203; 70934-770; 71610-433; 71610-435; 60687-242; 61919-086; 65841-044; 69097-834; 71093-130; 71335-0808; 72789-092; 16714-601; 16714-612; 16714-613; 16729-215; 50228-469; 53002-3192; 55154-4687; 55700-562; 55700-910; 63187-767; 63187-859; 64980-409; 65841-045; 68071-1317; 68071-1318; 68071-3146; 68071-4370; 70518-1350; 70518-2812; 72789-088; 72789-273; 80425-0200; 53869-4900; 53869-4910; 65977-0149; 16714-611; 31722-146; 42337-203; 50090-3203; 50228-468; 52427-664; 53002-1192; 61919-345; 68071-1911; 69097-833; 71205-205; 71335-0210; 71335-0718; 71335-1078; 71610-651; 53104-7590; 42708-092; 43063-033; 43353-447; 43353-970; 50090-6379; 53002-1215; 53808-1127; 59762-0067; 63187-795; 70518-1615; 71205-047; 72189-122; 72789-013; 65862-222; 65977-0002; 42337-202; 43602-981; 55700-340; 60760-091; 60760-612; 0049-4900; 68071-4973; 68788-6437; 70934-188; 71205-455; 71335-0328; 71335-0403; 71335-0510; 72865-206; 80425-0310; 53104-7578; 66022-0304; 16729-216; 16729-217; 42708-124; 43602-979; 50090-2071; 55700-977; 58118-0834; 60687-231; 63629-8774; 65841-043; 68788-6429; 68788-8109; 70518-1748; 70518-3145; 71093-129; 71093-131; 71205-028; 71335-0896; 62512-0080; 31722-147; 50090-3945; 53002-4215; 55700-362; 60760-737; 0049-4910; 0049-4960; 68071-2767; 68645-523; 68788-6835; 68788-7928; 70010-204; 70010-205; 70934-019; 71205-343; 72865-207; 53869-4960; 62350-0043; 83467-0001; 31722-145; 45865-518; 53002-1507; 53002-3215
UNII UTI8907Y6X
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H18Cl3N
CAS Registry Number 79559-97-0
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vasodilation procedure25.03.01.001--Not Available
Muscle relaxant therapy25.16.01.001--Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Cerebral vasoconstriction24.04.06.025; 17.08.02.012--Not Available
Angiopathy24.03.02.007--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Adhesion08.01.03.048--Not Available
Urine output increased13.13.03.002--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Benign neoplasm16.02.02.007--Not Available
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.11.01.003--Not Available
Connective tissue disorder15.06.01.006; 10.04.04.026--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Ill-defined disorder08.01.03.049--Not Available
Inner ear disorder04.04.02.002--Not Available
Lacrimal disorder06.08.02.005--Not Available
Blood disorder01.05.01.004--Not Available
Autonomic neuropathy17.05.01.009--Not Available
Psychotic disorder19.03.01.002--
Hepatobiliary disease09.01.08.003--Not Available
Respiratory tract infection22.07.07.001; 11.01.08.017--Not Available
Cystitis noninfective20.03.02.001--
Anorectal discomfort07.03.03.003--Not Available
Acute kidney injury20.01.03.016--
Reversible cerebral vasoconstriction syndrome24.04.06.026; 18.06.01.004; 17.08.02.014--Not Available
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