Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD).[L9016] Common off-label uses for sertraline include the prevention of post stroke depression[A187078], generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope.[L5227]
Marketing Status approved
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 76282-214; 23155-759; 68180-353; 55700-225; 63187-055; 70518-0153; 70518-1461; 70518-1617; 71335-9714; 0615-7990; 65427-009; 55154-3570; 0615-7991; 76282-212; 0904-6924; 50090-5848; 70518-1040; 23155-757; 70518-2512; 0904-6925; 68180-351; 68180-352; 68071-4400; 63187-212; 68788-7329; 0615-7989; 0904-6926; 55154-3569; 63187-478; 67296-1199; 70934-958; 76282-213; 23155-758; 50090-0989
UNII QUC7NX6WMB
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pulmonary toxicity22.01.02.007; 12.03.01.0130.000032%Not Available
Food intolerance14.02.01.0050.000013%Not Available
Pigmentation disorder23.05.03.0010.000019%Not Available
Poor quality sleep19.02.05.005; 17.15.04.0020.000066%Not Available
Muscle contracture15.03.05.0240.000013%Not Available
Facial spasm17.04.03.0100.000013%Not Available
Effusion08.01.03.0520.000038%Not Available
Postural orthostatic tachycardia syndrome17.05.01.019; 02.03.02.0200.000013%Not Available
Metamorphopsia06.02.06.014; 17.17.01.0200.000013%Not Available
Autism spectrum disorder17.03.05.003; 19.22.02.0020.000127%Not Available
Lichenoid keratosis23.01.01.0040.000066%Not Available
Dark circles under eyes08.01.03.054; 06.08.03.0190.000041%Not Available
Pulmonary arterial hypertension22.06.01.002; 24.08.03.0030.000070%Not Available
Head titubation17.01.06.0060.000013%Not Available
Aortic arteriosclerosis24.04.01.0040.000019%Not Available
Suicidal behaviour19.12.01.0060.000178%Not Available
Loose tooth07.09.05.0090.000013%Not Available
Cardiovascular insufficiency02.11.01.011; 24.06.03.0050.000013%Not Available
Substance abuse19.07.06.0180.000045%Not Available
Mixed liver injury09.01.07.0150.000064%Not Available
Activation syndrome19.06.02.008; 17.02.05.0410.000094%Not Available
Organising pneumonia22.01.02.0080.000045%Not Available
Adverse reaction08.06.01.0180.000032%Not Available
Low birth weight baby18.04.02.0030.000070%Not Available
Gastrointestinal sounds abnormal07.01.01.0020.000045%Not Available
Skin mass23.07.04.0140.000028%Not Available
Oromandibular dystonia17.01.03.0060.000164%Not Available
Brain injury19.07.03.007; 17.11.01.0030.000057%Not Available
Intellectual disability19.21.06.001; 17.03.07.0010.000051%Not Available
Hypertransaminasaemia09.01.02.0050.000019%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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