Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Samarium sm-153 lexidronam
Drug ID BADD_D01985
Description Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium Sm 153 lexidronam is used to help relieve the bone pain that may occur with certain kinds of cancer. The radioactive samarium is taken up in the bone cancer area and gives off radiation that helps provide relief of pain.
Indications and Usage Investigated for use/treatment in bone metastases, multiple myeloma, prostate cancer, and rheumatoid arthritis.
Marketing Status Prescription
ATC Code V10BX02
DrugBank ID DB05273
KEGG ID D08504
MeSH ID C061972
PubChem ID 177960
TTD Drug ID D0R3BC
NDC Product Code Not Available
Synonyms samarium Sm-153 lexidronam | samarium-153-EDTMP | 153Sm-EDTMP | samarium-153 lexidronam | samarium (153Sm) lexidronam | samarate(5-)-153Sm, (((1,2-ethanediylbis((nitrilo-kappa-N)bis(methylene)))tetrakis(phosphonato-kappa-O))(8-))-, pentahydrogen, (oc-6-21) | Quadramet | samarium ethylenediaminetetramethylenephosphonate | Sm-EDTMP
Chemical Information
Molecular Formula C6H12N2O12P4Sm-5
CAS Registry Number 154427-83-5
SMILES C(CN(CP(=O)([O-])[O-])CP(=O)([O-])[O-])N(CP(=O)([O-])[O-])CP(=O)([O-])[O-].[Sm+3 ]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Alopecia23.02.02.001--
Angina pectoris24.04.04.002; 02.02.02.002--
Arrhythmia02.03.02.001--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Cardiac failure congestive02.05.01.002--Not Available
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Coagulopathy01.01.02.001--Not Available
Cough22.02.03.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Epistaxis22.04.03.001; 24.07.01.005--
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin decreased13.01.05.003--Not Available
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Infection11.01.08.002--Not Available
Leukopenia01.02.02.001--Not Available
Lymphadenopathy01.09.01.002--Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Nausea07.01.07.001--
Oral candidiasis11.03.03.004; 07.05.07.001--Not Available
Pain08.01.08.004--
Paraesthesia17.02.06.005--
Pathological fracture16.32.03.007; 15.08.02.008; 12.04.02.006--Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Purpura23.06.01.004; 01.01.04.003; 24.07.06.005--
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