Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Salmeterol xinafoate
Drug ID BADD_D01982
Description Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol].[A190459] Salmeterol was first described in the literature in 1988.[A190477] Salmeterol's structure is similar to salbutamol's with an aralkyloxy-alkyl substitution on the amine.[A183737] Salmeterol was granted FDA approval on 4 February 1994.[L11542]
Indications and Usage For the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Marketing Status Prescription; Discontinued
ATC Code R03AC12
DrugBank ID DB00938
KEGG ID D00687
MeSH ID D000068299
PubChem ID 56801
TTD Drug ID D0L5YV
NDC Product Code 14501-0045; 63190-0650; 52482-002; 50909-4102; 0173-0521; 58032-0143; 53104-7541; 64567-0007; 52221-109; 15308-1021; 55018-402
Synonyms Salmeterol Xinafoate | Xinafoate, Salmeterol | Salmeterol | Serevent
Chemical Information
Molecular Formula C36H45NO7
CAS Registry Number 94749-08-3
SMILES C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O.C1=CC=C2C(=C1)C=CC(=C2O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Surgical and medical proceduresBeta-2 adrenergic receptorP07550T52522Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Asthma22.03.01.002; 10.01.03.010--Not Available
Atrial fibrillation02.03.03.002--
Bone pain15.02.01.001--
Bronchitis22.07.01.001; 11.01.09.001--
Choking22.02.05.001--Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Cough22.02.03.001--
Dermatitis contact12.03.01.040; 10.01.01.003; 23.03.04.004--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dyspepsia07.01.02.001--
Ear disorder04.03.01.001--Not Available
Eczema23.03.04.006--
Extrasystoles02.03.02.003--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal infection11.01.07.012; 07.19.02.005--Not Available
Headache17.14.01.001--
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hypertension24.08.02.001--
Influenza22.07.02.001; 11.05.03.001--Not Available
Keratitis06.04.02.002--
Laryngospasm22.04.02.002--
Lower respiratory tract infection22.07.01.002; 11.01.09.002--Not Available
Muscle rigidity17.05.02.005; 15.05.04.001--Not Available
Muscle spasms15.05.03.004--
Musculoskeletal pain15.03.04.007--
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