Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Salmeterol
Drug ID BADD_D01981
Description Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol].[A190459] Salmeterol was first described in the literature in 1988.[A190477] Salmeterol's structure is similar to salbutamol's with an aralkyloxy-alkyl substitution on the amine.[A183737] Salmeterol was granted FDA approval on 4 February 1994.[L11542]
Indications and Usage For the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Marketing Status Prescription; Discontinued
ATC Code R03AC12
DrugBank ID DB00938
KEGG ID D05792
MeSH ID D000068299
PubChem ID 5152
TTD Drug ID D0L5YV
NDC Product Code 63850-3912
Synonyms Salmeterol Xinafoate | Xinafoate, Salmeterol | Salmeterol | Serevent
Chemical Information
Molecular Formula C25H37NO4
CAS Registry Number 89365-50-4
SMILES C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Surgical and medical proceduresBeta-2 adrenergic receptorP07550T5252211804270; 11586955; 10988267; 10984540; 11306963; 10340917; 9399966
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.0100.022432%Not Available
Atrial fibrillation02.03.03.002--
Back pain15.03.04.005--
Body temperature increased13.15.01.001--Not Available
Bone pain15.02.01.001--
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm22.03.01.004; 10.01.03.012--
Bronchospasm paradoxical22.03.01.006--Not Available
Chest discomfort02.02.02.009; 22.02.08.001; 08.01.08.0190.022432%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Choking22.02.05.001--Not Available
Chronic obstructive pulmonary disease22.03.01.0070.003901%Not Available
Conjunctivitis06.04.01.002; 11.01.06.012--
Constipation07.02.02.001--
Cough22.02.03.001--
Dermatitis23.03.04.002--Not Available
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Drug hypersensitivity10.01.01.0010.014955%Not Available
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