| Drug Name |
Rosuvastatin calcium |
| Drug ID |
BADD_D01972 |
| Description |
Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid and is the third step in a sequence of metabolic reactions involved in the production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). Prescribing of statin medications is considered standard practice following any cardiovascular events and for people with a moderate to high risk of development of CVD, such as those with Type 2 Diabetes. The clear evidence of the benefit of statin use coupled with very minimal side effects or long term effects has resulted in this class becoming one of the most widely prescribed medications in North America.[A181087, A181406] |
| Indications and Usage |
Used as an adjunct to dietary therapy to treat primary hyperlipidemia (heterozygous familial and nonfamilial), mixed dyslipidemia and hypertriglyceridemia. Also indicated for homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering therapies or when other such therapies are not available. Furthermore, it is used to slow the progression of atherosclerosis and for primary prevention of cardiovascular disease. |
| Marketing Status |
Prescription |
| ATC Code |
C10AA07 |
| DrugBank ID |
DB01098
|
| KEGG ID |
D01915
|
| MeSH ID |
D000068718
|
| PubChem ID |
5282455
|
| TTD Drug ID |
D0JE2E
|
| NDC Product Code |
71209-045; 71610-187; 72205-002; 51407-153; 71335-1330; 71209-046; 71335-0905; 16714-990; 72640-013; 68788-7086; 70377-009; 50090-3437; 50090-5189; 70518-1819; 14501-0002; 71205-390; 50090-2449; 68071-4896; 68071-4765; 50090-5056; 60687-234; 59285-005; 63629-7057; 50090-5188; 0310-0755; 65862-295; 71335-1501; 0310-0752; 71610-232; 63629-7158; 71335-0302; 68788-7310; 69539-009; 16714-988; 59746-429; 71205-355; 16714-989; 70377-008; 70934-834; 71205-052; 71610-215; 63187-864; 65015-752; 50090-5110; 72189-106; 63187-869; 70934-275; 65727-028; 59746-430; 68071-5176; 71335-1717; 50090-3176; 50090-4710; 69218-0100; 54921-752; 16714-991; 68788-7612; 72205-005; 50090-5745; 13668-179; 65862-293; 68462-263; 72205-004; 66039-914; 68071-5258; 51407-156; 0310-0754; 82009-018; 47335-582; 66039-834; 69539-010; 65372-1176; 68071-3348; 68071-2637; 71335-1733; 68788-7947; 0310-0751; 71610-196; 82608-005; 71205-279; 63629-3381; 71335-1890; 0781-5403; 0310-7590; 71335-0068; 50090-4738; 68462-264; 66039-955; 65977-0077; 70518-2542; 72205-027; 43353-332; 68462-262; 50090-1097; 50090-3706; 71335-2035; 27808-156; 51407-154; 63187-865; 0781-5400; 50090-2451; 68071-5225; 55700-839; 0781-5402; 13668-180; 63629-4372; 65862-294; 82009-017; 71205-099; 71335-1017; 82009-020; 50090-4039; 47335-583; 62512-0062; 75945-030; 57237-169; 71205-008; 0904-6780; 70518-2774; 70377-006; 59746-431; 57237-170; 47335-585; 70518-0987; 71335-1889; 68462-261; 50923-0490; 68071-2407; 55111-863; 70518-2055; 63629-7157; 55154-8099; 69539-008; 70518-2090; 27808-158; 55289-932; 68071-2378; 54921-757; 49187-0200; 27808-157; 54921-755; 54921-751; 71335-1440; 47335-584; 71610-233; 68071-2379; 63187-872; 71610-133; 67877-442; 50090-5770; 63187-860; 71209-043; 51407-155; 54921-758; 65862-296; 71610-216; 0904-6778; 55488-0320; 68788-8135; 71205-078; 55289-935; 43547-592; 13668-182; 0310-7580; 0904-6779; 65862-304; 67877-441; 71335-0959; 68071-2634; 59746-428; 43547-591; 71335-2055; 42677-302; 71335-1103; 70377-007; 71205-475; 71610-078; 42677-301; 43547-593; 54921-754; 71610-234; 50090-3549; 50090-5468; 43353-339; 54921-759; 67877-439; 68578-0011; 57237-168; 50090-4056; 71335-1741; 60687-245; 13668-181; 71492-100; 0904-6781; 71205-176; 71205-077; 71335-1098; 69218-0600; 63629-8124; 43547-594; 60687-256; 69539-160; 71335-1939; 43353-352; 55700-885; 67877-440; 50090-3515; 50090-5116; 57237-171; 68071-4764; 27808-155; 79677-000; 54921-756; 71209-044; 50090-2447; 72205-003; 0781-5401; 82009-019 |
| Synonyms |
Rosuvastatin Calcium | Calcium, Rosuvastatin | Crestor | Rosuvastatin | ZD4522 | ZD 4522 |
