Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rimonabant hydrochloride
Drug ID BADD_D01947
Description Rimonabant is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. It is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite. Rimonabant is the first selective CB1 receptor blocker to be approved for use anywhere in the world. Rimonabant is approved in 38 countries including the E.U., Mexico, and Brazil. It was rejected for approval for use in the United States. This decision was made after a U.S. advisory panel recommended the medicine not be approved because it may increase suicidal thinking and depression.
Indications and Usage For use in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m2, or patients wih a BMI greater than 27 kg/m2 with associated risk factors, such as type 2 diabetes or dyslipidaemia.
Marketing Status Not Available
ATC Code A08AX01
DrugBank ID DB06155
KEGG ID D05731
MeSH ID D000077285
PubChem ID 104849
TTD Drug ID D0O3OS
NDC Product Code Not Available
Synonyms Rimonabant | SR141716 | SR 141716 | Rimonabant Hydrochloride | N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride | Zimulti | SR 141716A | SR-141716A | SR141716A | Acomplia
Chemical Information
Molecular Formula C22H22Cl4N4O
CAS Registry Number 158681-13-1
SMILES CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Aggression19.05.01.001--Not Available
Amnesia19.20.01.001; 17.03.02.001--
Anger19.04.02.001--Not Available
Anxiety19.06.02.002--
Asthenia08.01.01.001--Not Available
Delusion19.10.01.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Disturbance in attention19.21.02.002; 17.03.03.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dysphoria19.04.02.004--Not Available
Emotional disorder19.04.02.005--Not Available
Fatigue08.01.01.002--
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hiccups22.02.04.002; 07.01.06.009--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypoaesthesia17.02.06.023--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.001--
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Irritability19.04.02.013; 08.01.03.011--
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