Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Riluzole
Drug ID BADD_D01942
Description A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi.
Indications and Usage For the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)
Marketing Status approved; investigational
ATC Code N07XX02
DrugBank ID DB00740
KEGG ID D00775
MeSH ID D019782
PubChem ID 5070
TTD Drug ID D0H0KB
NDC Product Code 68462-381; 70510-2201; 42291-775; 0378-4145; 62756-538; 67877-286; 69076-200; 63278-1076; 65129-1011; 70515-700; 65977-0045; 66039-812
UNII 7LJ087RS6F
Synonyms Riluzole | 2-Amino-6-trifluoromethoxybenzothiazole | 2 Amino 6 trifluoromethoxybenzothiazole | Rilutek | RP-54274 | RP 54274 | RP54274 | PK-26124 | PK 26124 | PK26124
Chemical Information
Molecular Formula C8H5F3N2OS
CAS Registry Number 1744-22-5
SMILES C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Osteoporosis15.02.03.002; 14.04.04.002--
Pain08.01.08.004--
Palpitations02.11.04.012--
Pancreatic pseudocyst07.18.03.0020.000538%Not Available
Pancreatitis07.18.01.0010.001346%
Pancreatitis acute07.18.01.0020.004630%Not Available
Pancreatitis necrotising07.18.01.0040.000808%Not Available
Pancytopenia01.03.03.003--Not Available
Panophthalmitis06.04.05.005--Not Available
Paraesthesia23.03.03.094; 17.02.06.0050.001723%
Paranoia19.05.01.005--Not Available
Parathyroid disorder05.04.03.001--Not Available
Pericarditis02.06.02.001--
Peripheral vascular disorder24.03.01.003--Not Available
Peritonitis11.01.07.007; 07.19.05.004--
Peroneal nerve palsy17.09.02.0030.000808%Not Available
Personality change17.02.05.019; 19.05.01.006--
Personality disorder19.05.02.002--Not Available
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Phlebitis24.12.03.004; 12.02.01.002--
Photophobia17.17.02.006; 06.01.01.004--
Photosensitivity reaction23.03.09.003--
Platelet count decreased13.01.04.001--
Pleural disorder22.05.03.002--Not Available
Pleural effusion22.05.02.002--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumonia aspiration22.07.01.015; 11.01.09.019--Not Available
Pneumothorax22.05.02.003--
Pollakiuria20.02.02.007--
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