Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Riluzole
Drug ID BADD_D01942
Description A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi.
Indications and Usage For the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)
Marketing Status approved; investigational
ATC Code N07XX02
DrugBank ID DB00740
KEGG ID D00775
MeSH ID D019782
PubChem ID 5070
TTD Drug ID D0H0KB
NDC Product Code 68462-381; 70510-2201; 42291-775; 0378-4145; 62756-538; 67877-286; 69076-200; 63278-1076; 65129-1011; 70515-700; 65977-0045; 66039-812
UNII 7LJ087RS6F
Synonyms Riluzole | 2-Amino-6-trifluoromethoxybenzothiazole | 2 Amino 6 trifluoromethoxybenzothiazole | Rilutek | RP-54274 | RP 54274 | RP54274 | PK-26124 | PK 26124 | PK26124
Chemical Information
Molecular Formula C8H5F3N2OS
CAS Registry Number 1744-22-5
SMILES C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Shock24.06.02.002--Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Skin disorder23.03.03.007--Not Available
Skin reaction23.03.03.013; 10.01.03.0190.000538%Not Available
Skin ulcer24.04.03.007; 23.07.03.003--
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder19.19.02.002; 17.02.08.003; 22.12.03.0270.000808%Not Available
Stomatitis07.05.06.005--
Stridor22.04.02.003--
Stupor17.02.04.007; 19.02.05.004--Not Available
Subarachnoid haemorrhage24.07.04.004; 17.08.01.010; 12.01.10.011--Not Available
Subdural haematoma17.08.05.002; 12.01.10.003; 24.07.04.005--Not Available
Suicide attempt19.12.01.004--
Supraventricular tachycardia02.03.03.012--
Syncope02.11.04.015; 24.06.02.012; 17.02.04.008--
Tachycardia02.03.02.0070.000538%Not Available
Talipes03.11.07.007; 15.11.07.007--Not Available
Tension19.06.02.005--Not Available
Tetany15.05.03.013; 14.04.01.005; 05.04.02.003--Not Available
Thinking abnormal19.10.03.001; 17.02.05.023--Not Available
Thirst08.01.09.021; 14.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombocytopenic purpura23.06.01.007; 01.08.01.003--Not Available
Thrombosis24.01.01.006--Not Available
Thyroid neoplasm16.24.01.002; 05.02.05.002--Not Available
Tongue discolouration07.14.02.006--Not Available
Tooth disorder07.09.05.001--Not Available
Tremor17.01.06.002--
Trismus17.01.03.004; 15.05.04.004--
Ulcer08.03.06.001--Not Available
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