Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rilonacept
Drug ID BADD_D01939
Description Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold auto-inflammatory syndrome (FCAS) and Muckle-Wells Syndrome (MWS), in adults and children greater than 12 years old.
Indications and Usage Rilonacept is currently used in the treatment of cryopyrin-associated periodic syndrome. In May 2012, an advisory panel for the FDA voted 11-0 against the use of Rilonacept for the treatment of gout.
Marketing Status Prescription
ATC Code L04AC04
DrugBank ID DB06372
KEGG ID D06635
MeSH ID C531377
PubChem ID Not Available
TTD Drug ID D09DBY
NDC Product Code 65044-7168; 73604-914
Synonyms rilonacept | interleukin-1 Trap
Chemical Information
Molecular Formula Not Available
CAS Registry Number 501081-76-1
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain upper07.01.05.003--
Blister23.03.01.001; 12.01.06.002--Not Available
Blood cholesterol decreased13.12.01.001--Not Available
Cough22.02.03.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Erythema23.03.06.001--Not Available
Feeling hot08.01.09.009--Not Available
Hypoaesthesia17.02.06.023--Not Available
Infection11.01.08.002--Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
Lipids decreased13.12.02.005--Not Available
Mass08.03.05.003--Not Available
Nausea07.01.07.001--
Neutropenia01.02.03.004--Not Available
Neutrophil count13.01.06.046--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain08.01.08.004--
Pruritus23.03.12.001--
Sinusitis22.07.03.007; 11.01.13.005--
Swelling08.01.03.015--Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary tract infection11.01.14.004; 20.08.02.001--
Urticaria23.04.02.001; 10.01.06.001--
Contusion24.07.06.001; 23.03.11.002; 15.03.01.008; 12.01.06.001--
Haemorrhage24.07.01.002--Not Available
Inflammation08.01.05.007--Not Available
Antibody test positive13.06.03.001--Not Available
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