Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rifaximin
Drug ID BADD_D01938
Description Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduction in risk of overt hepatic encephalopathy recurrence; as well as diarrhea-predominant irritable bowel syndrome (IBS-D) in adult women and men. It is marketed under the brand name Xifaxan by Salix Pharmaceuticals.
Indications and Usage Rifaximin has multiple indications by the FDA: for the treatment of patients (≥12 years of age) with traveller's diarrhea caused by noninvasive strains of Escherichia coli; for the reduction of overt hepatic encephalopathy recurrence in patients ≥18 years of age; and in May 2015 it was approved for irritable bowel syndrome with diarrhea (IBS-D) treatment in adult men and women.
Marketing Status approved; investigational
ATC Code A07AA11; D06AX11
DrugBank ID DB01220
KEGG ID D02554
MeSH ID D000078262
PubChem ID 6436173
TTD Drug ID D04ITO
NDC Product Code 14501-0082; 17337-0043; 17337-0044; 73309-232; 17337-0032; 57297-029; 65649-303; 10695-011; 14501-0093; 65649-301; 12828-0089; 62207-017; 76278-1109; 50090-2445; 55154-6777; 59285-008; 70799-000; 73377-184; 14501-0021
UNII L36O5T016N
Synonyms Rifaximin | 4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin | L 105 | L-105 | L105 | Redactiv | Xifaxan
Chemical Information
Molecular Formula C43H51N3O11
CAS Registry Number 80621-81-4
SMILES CC1C=CC=C(C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)OC(C4=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O )C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rhinorrhoea22.12.03.021--
Shock24.06.02.002--Not Available
Skin disorder23.03.03.007--Not Available
Skin exfoliation23.03.07.0030.000868%Not Available
Skin fragility23.03.03.0090.000322%Not Available
Sunburn23.03.09.007; 12.05.02.001--Not Available
Swelling face08.01.03.100; 23.04.01.018; 10.01.05.018--Not Available
Syncope02.11.04.015; 24.06.02.012; 17.02.04.008--
Therapeutic response unexpected08.06.01.0010.001254%Not Available
Throat irritation22.12.03.029; 07.05.05.0370.001093%Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 10.01.01.006; 11.07.01.0060.000482%
Tremor17.01.06.002--
Upper gastrointestinal haemorrhage24.07.02.024; 07.12.02.0060.000322%
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vertigo17.02.12.002; 04.04.01.003--
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Mental status changes19.07.01.0010.001029%Not Available
Peripheral swelling08.01.03.053; 02.05.04.0150.003858%Not Available
Localised oedema14.05.06.009; 08.01.07.011; 02.05.04.0060.000482%
Contusion15.03.05.007; 24.07.06.001; 23.03.11.002; 12.01.06.001--
Cardiopulmonary failure22.02.06.004; 02.05.01.0040.000322%Not Available
Dysentery11.01.07.010; 07.19.01.006--Not Available
Sticky skin23.03.03.019--Not Available
Lymphatic disorder01.09.01.003--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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