Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Retapamulin
Drug ID BADD_D01928
Description Retapamulin, marketed by GlaxoSmithKline as the ointment Altabax, is an antibiotic for skin infections like impetigo. It was approved by the FDA in April 2007.
Indications and Usage For use in adults and pediatric patients aged 9 months and older for the topical treatment of impetigo (up to 100 cm2 in total area in adults or 2% total body surface area in pediatric patients aged 9 months or older) due to Staphylococcus aureus (methicillin-susceptible isolates only) or Streptococcus pyogenes.
Marketing Status Prescription
ATC Code D06AX13
DrugBank ID DB01256
KEGG ID D05720
MeSH ID C508887
PubChem ID 6918462
TTD Drug ID D03UQM
NDC Product Code 16110-518
Synonyms retapamulin | acetic acid, 2-(((3-exo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)thio)-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester | SB 275833 | SB275833 | SB-275833 | Altabax | Altargo
Chemical Information
Molecular Formula C30H47NO4S
CAS Registry Number 224452-66-8
SMILES CC1CCC23CCC(=O)C2C1(C(CC(C(C3C)O)(C)C=C)OC(=O)CSC4CC5CCC(C4)N5C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Angioedema10.01.05.009; 23.04.01.001--Not Available
Application site irritation12.07.01.003; 08.02.01.003--Not Available
Application site pain12.07.01.004; 08.02.01.004--Not Available
Application site pruritus23.03.12.004; 12.07.01.005; 08.02.01.005--Not Available
Blood creatine phosphokinase increased13.04.01.001--
Body temperature increased13.15.01.001--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Diarrhoea07.02.01.001--
Eczema23.03.04.006--
Erythema23.03.06.001--Not Available
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Immune system disorder10.02.01.001--Not Available
Instillation site pain12.07.01.008; 08.02.01.008--Not Available
Nasopharyngitis11.01.13.002; 22.07.03.002--Not Available
Nausea07.01.07.001--
Pain08.01.08.004--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Skin disorder23.03.03.007--Not Available
Application site paraesthesia08.02.01.026; 17.02.06.012; 12.07.01.026--Not Available
Application site burn23.03.11.013; 12.07.01.038; 08.02.01.038--Not Available
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