Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Reboxetine
Drug ID BADD_D01919
Description Reboxetine is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesylate (i.e. methanesulfonate) salt is sold under tradenames including Edronax, Norebox, Prolift, Solvex, Davedax or Vestra. Reboxetine has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine.
Indications and Usage For the treatment of clinical depression.
Marketing Status approved; experimental
ATC Code N06AX18
DrugBank ID DB00234
KEGG ID D08472
MeSH ID D000077593
PubChem ID 127151
TTD Drug ID D0N8FQ
NDC Product Code Not Available
UNII 947S0YZ36I
Synonyms Reboxetine | Reboxetine Mesylate | 2-((2-Ethoxyphenoxy)benzyl)morpholine methanesulfonate | Vestra
Chemical Information
Molecular Formula C19H23NO3
CAS Registry Number 71620-89-8
SMILES CCOC1=CC=CC=C1OC(C2CNCCO2)C3=CC=CC=C3
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Accommodation disorder06.02.04.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Akathisia19.06.02.006; 17.01.02.002--
Alanine aminotransferase increased13.03.04.005--
Albuminuria20.02.01.001--Not Available
Amenorrhoea21.01.02.001; 05.05.01.002--
Anaemia01.03.02.001--
Anorectal disorder07.03.01.001--Not Available
Anorgasmia19.08.01.001--
Anxiety19.06.02.002--
Aphasia19.21.01.001; 17.02.03.001--
Asthenia08.01.01.001--Not Available
Blood creatinine increased13.13.01.004--
Blood pressure fluctuation24.06.01.002--Not Available
Blood pressure systolic increased13.14.03.006--Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Breath odour07.01.06.002--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Cerebral ischaemia24.04.06.003; 17.08.01.005--
Cheilitis23.03.03.025; 07.05.01.001--
Chest pain02.02.02.011; 22.12.02.003; 08.01.08.002--Not Available
Chills15.05.03.016; 08.01.09.001--
Conduction disorder02.03.01.008--
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis06.04.01.002; 11.01.06.012--
Constipation07.02.02.001--
Coordination abnormal17.02.02.004--Not Available
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