Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ranolazine
Drug ID BADD_D01915
Description Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities.[A189234] Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms.[L3580] With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.[L5440]
Indications and Usage For the treatment of chronic angina. It should be used in combination with amlodipine, beta-blockers or nitrates.
Marketing Status Prescription; Discontinued
ATC Code C01EB18
DrugBank ID DB00243
KEGG ID D05700
MeSH ID D000069458
PubChem ID 56959
TTD Drug ID D03HYQ
NDC Product Code 65841-034; 47335-625; 50228-423; 43353-880; 51407-225; 67877-525; 50370-0019; 67877-526; 50228-424; 69097-222; 70625-206; 45963-418; 68462-320; 47335-624; 71610-518; 51604-1154; 65862-981; 68462-319; 15308-0718; 69367-294; 27241-126; 61958-1003; 48087-0106; 69367-293; 42291-774; 63304-017; 48087-0082; 53747-042; 69097-221; 65162-379; 71610-322; 27241-125; 71205-868; 45963-419; 61958-1004; 51407-226; 71205-867; 68180-355; 42385-964; 67651-0258; 70756-703; 42571-325; 70756-704; 72578-064; 63304-018; 68180-354; 42291-773; 66039-943; 73680-0012; 11014-0108; 62512-0076; 72640-001; 42571-324; 47621-304; 67835-0011; 42385-963; 63552-143; 64552-4024; 63552-142; 67651-0224; 65372-1190; 70966-0008; 40006-043; 70771-1499; 72578-065; 60687-549; 70625-207; 70771-1500; 65162-376
Synonyms Ranolazine | N-(2,6-dimethylphenyl)-4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-1-piperazineacetamide | Renolazine | Ranolazine Hydrochloride | Hydrochloride, Ranolazine | Ranolazine Dihydrochloride | Dihydrochloride, Ranolazine | Ranolazine HCl | HCl, Ranolazine | Ranexa | RS 43285-193 | RS 43285 193 | RS 43285193 | RS 43285 | 43285, RS | RS-43285 | RS43285
Chemical Information
Molecular Formula C24H33N3O4
CAS Registry Number 95635-55-5
SMILES CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Throat tightness22.02.05.015; 19.01.02.0050.001432%Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombocytosis01.08.02.001--Not Available
Tinnitus17.04.07.004; 04.04.01.0020.004296%
Torsade de pointes02.03.04.0050.004296%Not Available
Transient ischaemic attack17.08.04.001; 24.04.06.005--
Tremor17.01.06.0020.024345%
Urethral disorder20.07.01.002--Not Available
Urinary retention20.02.02.0110.005728%
Urinary tract disorder20.08.01.001--Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria10.01.06.001; 23.04.02.001--
Vasodilatation24.03.02.003; 23.06.05.0060.001432%Not Available
Ventricular arrhythmia02.03.04.0060.000560%
Ventricular extrasystoles02.03.04.0070.001432%Not Available
Ventricular fibrillation02.03.04.0080.000747%
Ventricular tachycardia02.03.04.0100.009309%
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.0070.006444%
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Mental status changes19.07.01.001--Not Available
Mobility decreased17.02.05.018; 15.03.01.003; 08.01.03.0300.001432%Not Available
Carotid bruit13.14.06.0010.002148%Not Available
Underweight14.03.02.017--Not Available
Ischaemic cardiomyopathy24.04.04.019; 02.04.01.0040.001121%Not Available
Hypoacusis04.02.01.0060.005012%
Peripheral swelling08.01.03.053; 02.05.04.015--Not Available
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