Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ranolazine
Drug ID BADD_D01915
Description Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities.[A189234] Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms.[L3580] With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.[L5440]
Indications and Usage For the treatment of chronic angina. It should be used in combination with amlodipine, beta-blockers or nitrates.
Marketing Status Prescription; Discontinued
ATC Code C01EB18
DrugBank ID DB00243
KEGG ID D05700
MeSH ID D000069458
PubChem ID 56959
TTD Drug ID D03HYQ
NDC Product Code 65841-034; 47335-625; 50228-423; 43353-880; 51407-225; 67877-525; 50370-0019; 67877-526; 50228-424; 69097-222; 70625-206; 45963-418; 68462-320; 47335-624; 71610-518; 51604-1154; 65862-981; 68462-319; 15308-0718; 69367-294; 27241-126; 61958-1003; 48087-0106; 69367-293; 42291-774; 63304-017; 48087-0082; 53747-042; 69097-221; 65162-379; 71610-322; 27241-125; 71205-868; 45963-419; 61958-1004; 51407-226; 71205-867; 68180-355; 42385-964; 67651-0258; 70756-703; 42571-325; 70756-704; 72578-064; 63304-018; 68180-354; 42291-773; 66039-943; 73680-0012; 11014-0108; 62512-0076; 72640-001; 42571-324; 47621-304; 67835-0011; 42385-963; 63552-143; 64552-4024; 63552-142; 67651-0224; 65372-1190; 70966-0008; 40006-043; 70771-1499; 72578-065; 60687-549; 70625-207; 70771-1500; 65162-376
Synonyms Ranolazine | N-(2,6-dimethylphenyl)-4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-1-piperazineacetamide | Renolazine | Ranolazine Hydrochloride | Hydrochloride, Ranolazine | Ranolazine Dihydrochloride | Dihydrochloride, Ranolazine | Ranolazine HCl | HCl, Ranolazine | Ranexa | RS 43285-193 | RS 43285 193 | RS 43285193 | RS 43285 | 43285, RS | RS-43285 | RS43285
Chemical Information
Molecular Formula C24H33N3O4
CAS Registry Number 95635-55-5
SMILES CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Type 2 diabetes mellitus14.06.01.003; 05.06.01.003--Not Available
Acute kidney injury20.01.03.016--
Medication residue present13.15.01.0320.013605%Not Available
Cardiac failure chronic02.05.01.0090.000374%Not Available
Catheterisation cardiac13.14.07.0030.006444%Not Available
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