Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ranolazine
Drug ID BADD_D01915
Description Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities.[A189234] Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms.[L3580] With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.[L5440]
Indications and Usage For the treatment of chronic angina. It should be used in combination with amlodipine, beta-blockers or nitrates.
Marketing Status Prescription; Discontinued
ATC Code C01EB18
DrugBank ID DB00243
KEGG ID D05700
MeSH ID D000069458
PubChem ID 56959
TTD Drug ID D03HYQ
NDC Product Code 65841-034; 47335-625; 50228-423; 43353-880; 51407-225; 67877-525; 50370-0019; 67877-526; 50228-424; 69097-222; 70625-206; 45963-418; 68462-320; 47335-624; 71610-518; 51604-1154; 65862-981; 68462-319; 15308-0718; 69367-294; 27241-126; 61958-1003; 48087-0106; 69367-293; 42291-774; 63304-017; 48087-0082; 53747-042; 69097-221; 65162-379; 71610-322; 27241-125; 71205-868; 45963-419; 61958-1004; 51407-226; 71205-867; 68180-355; 42385-964; 67651-0258; 70756-703; 42571-325; 70756-704; 72578-064; 63304-018; 68180-354; 42291-773; 66039-943; 73680-0012; 11014-0108; 62512-0076; 72640-001; 42571-324; 47621-304; 67835-0011; 42385-963; 63552-143; 64552-4024; 63552-142; 67651-0224; 65372-1190; 70966-0008; 40006-043; 70771-1499; 72578-065; 60687-549; 70625-207; 70771-1500; 65162-376
Synonyms Ranolazine | N-(2,6-dimethylphenyl)-4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-1-piperazineacetamide | Renolazine | Ranolazine Hydrochloride | Hydrochloride, Ranolazine | Ranolazine Dihydrochloride | Dihydrochloride, Ranolazine | Ranolazine HCl | HCl, Ranolazine | Ranexa | RS 43285-193 | RS 43285 193 | RS 43285193 | RS 43285 | 43285, RS | RS-43285 | RS43285
Chemical Information
Molecular Formula C24H33N3O4
CAS Registry Number 95635-55-5
SMILES CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams19.02.03.001; 17.15.02.0010.002148%Not Available
Acute myocardial infarction02.02.02.001; 24.04.04.0010.005012%Not Available
Agitation17.02.05.012; 19.06.02.001--
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.001--Not Available
Amnesia19.20.01.001; 17.03.02.0010.003580%
Anaemia01.03.02.001--
Angina pectoris24.04.04.002; 02.02.02.0020.035802%
Angina unstable24.04.04.004; 02.02.02.0040.002148%Not Available
Angioedema10.01.05.009; 23.04.01.0010.005728%Not Available
Anxiety19.06.02.002--
Aortic stenosis24.04.01.0010.001432%Not Available
Arrhythmia02.03.02.0010.002864%Not Available
Arteriosclerosis24.04.02.0010.000374%Not Available
Arteriosclerosis coronary artery24.04.04.012; 02.02.01.0110.000934%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.0010.002864%
Arthropathy15.01.01.0030.001432%Not Available
Asthenia08.01.01.0010.017185%Not Available
Asthma22.03.01.002; 10.01.03.0100.002148%Not Available
Ataxia17.02.02.001; 08.01.02.0040.002864%
Atrial fibrillation02.03.03.0020.007876%
Atrioventricular block complete02.03.01.0030.001432%
Back pain15.03.04.005--
Blindness17.17.01.003; 06.02.02.0010.004296%Not Available
Blood cholesterol increased13.12.01.0020.001432%
Blood creatine increased13.13.01.0010.001432%Not Available
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