Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ranitidine hydrochloride
Drug ID BADD_D01914
Description Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818] Ranitidine is often referred to as Zantac, and is available in various forms, including tablet, injection, and effervescent tablet preparations.[L10818,F4253] The prevalence of GERD is thought to be 10-20% in western countries.[A176843] Ranitidine has proven to be an effective treatment for relieving uncomfortable symptoms of gastric acid associated conditions and is therefore widely used in GERD and other gastric-acid related conditions.[A176849,L10818]
Indications and Usage Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Marketing Status Prescription; OTC; Discontinued
ATC Code A02BA02
DrugBank ID DB00863
KEGG ID D00673
MeSH ID D011899
PubChem ID 3033332
TTD Drug ID D0B8WN
NDC Product Code 65841-763; 72375-0002; 50090-4353; 0781-2865; 58032-2002; 68382-423; 59556-945; 67835-0004; 72785-0001; 65841-764; 70710-1550; 38779-0536; 72969-086; 73377-035; 52482-005; 55111-862; 70910-0001; 54838-550; 72643-012; 60505-2881; 55111-130; 0781-2855; 67091-244; 68382-422; 49711-0107; 38779-3186; 55111-002; 60505-0160; 49452-6214; 55111-129
Synonyms Ranitidine | Ranitidin | N (2-(((5-((Dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine | Biotidin | Ranisen | Sostril | Zantac | Zantic | AH-19065 | AH 19065 | AH19065 | Ranitidine Hydrochloride | Hydrochloride, Ranitidine
Chemical Information
Molecular Formula C13H23ClN4O3S
CAS Registry Number 66357-59-3
SMILES CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Vitamin B12 deficiencyCobalamin binding intrinsic factorP27352Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Insomnia17.15.03.002; 19.02.01.002--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Leukopenia01.02.02.001--Not Available
Loss of libido19.08.03.003--Not Available
Malaise08.01.01.003--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.003--Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Somnolence17.02.04.006; 19.02.05.003--
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Vasculitis24.05.02.001; 10.02.02.006--
Ventricular extrasystoles02.03.04.007--Not Available
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred06.02.06.007; 17.17.01.010--
Vomiting07.01.07.003--
Tubulointerstitial nephritis20.05.02.002--Not Available
Breast disorder21.05.04.004--Not Available
Motor dysfunction17.02.10.004--Not Available
Erectile dysfunction21.03.01.007; 19.08.04.001--
Blood count abnormal13.01.07.001--Not Available
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