Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ranitidine hydrochloride
Drug ID BADD_D01914
Description Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818] Ranitidine is often referred to as Zantac, and is available in various forms, including tablet, injection, and effervescent tablet preparations.[L10818,F4253] The prevalence of GERD is thought to be 10-20% in western countries.[A176843] Ranitidine has proven to be an effective treatment for relieving uncomfortable symptoms of gastric acid associated conditions and is therefore widely used in GERD and other gastric-acid related conditions.[A176849,L10818]
Indications and Usage Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Marketing Status Prescription; OTC; Discontinued
ATC Code A02BA02
DrugBank ID DB00863
KEGG ID D00673
MeSH ID D011899
PubChem ID 3033332
TTD Drug ID D0B8WN
NDC Product Code 65841-763; 72375-0002; 50090-4353; 0781-2865; 58032-2002; 68382-423; 59556-945; 67835-0004; 72785-0001; 65841-764; 70710-1550; 38779-0536; 72969-086; 73377-035; 52482-005; 55111-862; 70910-0001; 54838-550; 72643-012; 60505-2881; 55111-130; 0781-2855; 67091-244; 68382-422; 49711-0107; 38779-3186; 55111-002; 60505-0160; 49452-6214; 55111-129
Synonyms Ranitidine | Ranitidin | N (2-(((5-((Dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine | Biotidin | Ranisen | Sostril | Zantac | Zantic | AH-19065 | AH 19065 | AH19065 | Ranitidine Hydrochloride | Hydrochloride, Ranitidine
Chemical Information
Molecular Formula C13H23ClN4O3S
CAS Registry Number 66357-59-3
SMILES CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Vitamin B12 deficiencyCobalamin binding intrinsic factorP27352Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Atrioventricular block02.03.01.002--Not Available
Blood creatinine increased13.13.01.004--
Bradycardia02.03.02.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Eosinophilia01.02.04.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Galactorrhoea05.03.04.002; 21.05.02.002--Not Available
Granulocytopenia01.02.03.003--Not Available
Gynaecomastia21.05.04.003; 05.05.02.003--
Haemolytic anaemia01.06.03.002--Not Available
Hallucination19.10.02.002--
Hepatic failure09.01.03.002--
Hepatitis09.01.07.004--Not Available
Hepatitis cholestatic09.01.01.002--Not Available
Hypersensitivity10.01.03.003--
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