Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Raltitrexed
Drug ID BADD_D01907
Description Raltitrexed (brand name Tomudex®) is a chemotherapy drug manufactured AstraZeneca Company, is an antimetabolite used in chemotherapy. It is an inhibitor of thymidylate synthase.
Indications and Usage For the treatment of malignant neoplasm of colon and rectum
Marketing Status Not Available
ATC Code L01BA03
DrugBank ID DB00293
KEGG ID D01064
MeSH ID C068874
PubChem ID 135400182
TTD Drug ID D01KKQ
NDC Product Code Not Available
Synonyms raltitrexed | N-(5-(N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino)-2-thenoyl)-L-glutamic acid | ICI D1694 | ICI-D1694 | ZD 1694 | ZD1694 | ZD-1694 | D1694 | D 1694 | D-1694 | Tomudex
Chemical Information
Molecular Formula C21H22N4O6S
CAS Registry Number 112887-68-0
SMILES CC1=NC2=C(C=C(C=C2)CN(C)C3=CC=C(S3)C(=O)NC(CCC(=O)O)C(=O)O)C(=O)N1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Malaise08.01.01.003--
Mouth ulceration07.05.06.004--Not Available
Nausea07.01.07.001--
Necrosis24.04.02.006; 08.03.03.001--Not Available
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain08.01.08.004--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Renal failure20.01.03.005--Not Available
Sepsis11.01.11.003--
Sinus tachycardia02.03.03.010--
Skin exfoliation23.03.07.003--Not Available
Stomatitis07.05.06.005--
Supraventricular tachycardia02.03.03.012--
Thrombocytopenia01.08.01.002--Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Colorectal cancer metastatic07.21.01.005; 16.13.01.005--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Decreased appetite08.01.09.028; 14.03.01.005--
Ill-defined disorder08.01.03.049--Not Available
Renal impairment20.01.03.010--Not Available
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