Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rabeprazole
Drug ID BADD_D01898
Description Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Indications and Usage For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
Marketing Status Prescription; Discontinued
ATC Code A02BC04
DrugBank ID DB01129
KEGG ID D08463
MeSH ID D064750
PubChem ID 5029
TTD Drug ID D0KL4J
NDC Product Code 65162-724
Synonyms Rabeprazole | 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole | Dexrabeprazole | E 3810 | E3810 | Pariet | Rabeprazole Sodium | Sodium, Rabeprazole | 1H-Benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt | Aciphex | LY-307640 | LY 307640 | LY307640
Chemical Information
Molecular Formula C18H21N3O3S
CAS Registry Number 117976-89-3
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Benign neoplasm of skin23.10.01.006; 16.26.01.006--Not Available
Bladder pain20.02.02.001--Not Available
Blepharitis23.03.04.012; 06.04.04.001--Not Available
Blood creatine phosphokinase increased13.04.01.0010.001790%
Blood pressure increased13.14.03.0050.002386%Not Available
Body temperature increased13.15.01.001--Not Available
Bone pain15.02.01.001--
Bradycardia02.03.02.002--Not Available
Breast enlargement21.05.04.001--Not Available
Breast neoplasm21.05.01.004; 16.10.02.001--Not Available
Breast pain21.05.05.003--
Bronchitis22.07.01.001; 11.01.09.001--
Bundle branch block02.03.01.009--Not Available
Bursitis15.04.01.001--Not Available
Capillary fragility increased13.01.02.022--Not Available
Cardiac arrest02.03.04.0010.000311%
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Cataract06.06.01.001--
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.004176%Not Available
Chills15.05.03.016; 08.01.09.001--
Cholangitis09.02.01.002--Not Available
Cholecystitis09.03.01.001--
Cholelithiasis09.03.01.0020.001193%Not Available
Clostridium difficile colitis11.02.02.004; 07.19.01.0040.001193%Not Available
Colitis07.08.01.001--
Colitis ulcerative10.02.01.004; 07.08.01.0050.001193%Not Available
Coma17.02.09.0010.001790%Not Available
Confusional state19.13.01.001; 17.02.03.0050.002386%
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