Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Quetiapine fumarate
Drug ID BADD_D01889
Description Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder.[L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high sensitivity to other drugs, such as [Clozapine] and [Olanzapine].[A2189]
Indications and Usage For the treatment of schizophrenia and related psychotic disorders.
Marketing Status Prescription; Discontinued
ATC Code N05AH04
DrugBank ID DB01224
KEGG ID D00458
MeSH ID D000069348
PubChem ID 441261
TTD Drug ID D0H7KF
NDC Product Code 67877-249; 71335-0772; 52817-162; 29300-150; 50268-634; 70518-1018; 50090-3342; 68180-613; 63629-4776; 12780-4930; 0904-6642; 59765-145; 65862-493; 70518-2102; 0904-6643; 65015-699; 52817-163; 16571-720; 70518-2522; 14799-1102; 62331-039; 50268-630; 67296-1243; 50742-639; 59765-146; 34908-639; 65862-495; 71335-1519; 55111-190; 51407-068; 68180-449; 16729-097; 65862-494; 68554-0024; 65862-490; 68180-447; 34908-636; 59765-150; 63739-677; 68554-0089; 65862-489; 71610-128; 71610-141; 16729-096; 0781-5344; 55700-941; 69037-0064; 0904-6641; 34908-638; 71610-136; 55111-189; 68001-514; 55111-186; 50268-632; 50090-3198; 16571-717; 70518-2502; 49711-1506; 16364-146; 63187-219; 0781-5343; 33342-104; 50742-638; 68001-511; 51407-074; 13668-153; 61919-911; 70518-2701; 16364-149; 0904-6638; 16571-722; 47335-905; 29300-148; 71335-0926; 29300-149; 68180-445; 29300-147; 50268-631; 47335-907; 70518-0645; 70518-2016; 65862-492; 51407-073; 16436-0061; 0904-6801; 15894-0005; 52817-160; 68071-1892; 16729-109; 16571-721; 47335-903; 70518-2672; 29300-152; 0054-0229; 55111-188; 0781-5346; 52817-161; 46708-863; 51407-076; 67877-246; 52817-164; 47335-902; 71335-1353; 55289-187; 70518-2424; 67877-247; 33342-103; 46708-139; 65096-0106; 71205-031; 59765-147; 70518-2466; 68180-448; 71335-1562; 50090-3983; 67877-250; 0904-6640; 16571-718; 16571-809; 71335-1462; 66651-910; 51407-066; 0904-6805; 50090-3540; 67877-242; 67296-1582; 67877-248; 53747-101; 63629-4964; 68180-446; 55111-053; 55111-249; 50090-3333; 70518-1841; 46708-137; 55111-606; 50090-4022; 43353-008; 70518-1034; 55154-7894; 70518-2752; 33342-100; 65862-491; 0904-6802; 70518-2726; 72189-340; 63629-4841; 59765-149; 59285-024; 68180-450; 50090-5442; 50090-3379; 16729-132; 68069-0006; 71610-127; 0904-6639; 67296-1394; 51407-077; 38779-3081; 43353-957; 47335-906; 77777-114; 59765-148; 13668-148; 0904-6803; 55700-903; 51407-067; 43353-004; 50090-5473; 68788-7960; 68788-9487; 46708-136; 13668-150; 13668-151; 53296-0061; 11712-700; 33342-105; 33342-099; 22365-009; 63187-269; 15308-0320; 67877-245; 70518-2702; 70518-1918; 55289-447; 71335-1362; 73005-0003; 68001-513; 68788-7813; 34908-637; 0054-0221; 46708-135; 62756-628; 51407-075; 70518-2454; 50742-637; 70518-0974; 0904-6804; 51407-071; 76072-1009; 63187-452; 16364-148; 0781-5347; 50090-5884; 68180-612; 63739-665; 71052-653; 0054-0220; 70518-2523; 67296-1336; 50923-0483; 71610-140; 71335-1709; 16364-145; 43353-955; 50090-3303; 52932-0735; 55111-169; 55154-8092; 50742-635; 50268-633; 65372-1114; 50268-635; 33342-101; 50742-636; 16364-147; 65862-262; 70518-3190; 80425-0186; 68001-515; 13668-152; 0781-5342; 68180-615; 51407-069; 63739-690; 0054-0230; 12666-0008; 46708-138; 47335-904; 68788-7950; 29300-151; 16729-095; 0781-5348; 43353-011; 55154-7881; 13668-149; 51407-070; 68180-614; 68788-8065; 66577-033; 46708-134; 48087-0068; 68180-616; 16571-719; 70518-2901; 68001-512; 55289-872; 16364-150; 55154-3359; 50090-3377; 70518-0975; 0781-5345; 60429-416; 80425-0184; 0054-0222; 0054-0223
Synonyms Quetiapine Fumarate | Ethanol, 2-(2-(4-dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)-, (E)-2-butenedioate (2:1) (salt) | Seroquel | ICI 204,636 | ICI-204636 | ICI204636 | ICI 204636 | Quetiapine | 2-(2-(4-dibenzo(b,f)(1,4)thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol
Chemical Information
Molecular Formula C46H54N6O8S2
CAS Registry Number 111974-72-2
SMILES C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42.C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4= CC=CC=C42.C(=CC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Accommodation disorder06.02.04.001--Not Available
Acne23.02.01.001--Not Available
Aggression19.05.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.002--
Alanine aminotransferase increased13.03.01.003--
Alcohol intolerance14.02.01.001--
Amblyopia06.02.01.001--Not Available
Amenorrhoea21.01.02.001; 05.05.01.002--
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angina pectoris24.04.04.002; 02.02.02.002--
Anxiety19.06.02.002--
Apathy19.04.04.002--Not Available
Aphasia19.21.01.001; 17.02.03.001--
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atrial fibrillation02.03.03.002--
Atrioventricular block first degree02.03.01.004--
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