Pharmaceutical Information |
Drug Name |
Protriptyline hydrochloride |
Drug ID |
BADD_D01873 |
Description |
Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, alpha1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression. |
Indications and Usage |
For the treatment of depression. |
Marketing Status |
Prescription; Discontinued |
ATC Code |
N06AA11 |
DrugBank ID |
DB00344
|
KEGG ID |
D00484
|
MeSH ID |
D011530
|
PubChem ID |
6603149
|
TTD Drug ID |
D00MYQ
|
NDC Product Code |
63629-8346; 42794-004; 42806-097; 42794-007; 46438-0066; 0054-0211; 50383-960; 64980-158; 50383-959; 42806-096; 64980-159; 46438-0056; 17337-0539; 0054-0210 |
Synonyms |
Protriptyline | Vivactil | Protriptyline Hydrochloride | Hydrochloride, Protriptyline |
|
Chemical Information |
Molecular Formula |
C19H22ClN |
CAS Registry Number |
1225-55-4 |
SMILES |
CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13.Cl |
Chemical Structure |
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ADR Related Proteins Induced by Drug |
ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
Not Available | Not Available | Not Available | Not Available | Not Available |
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ADRs Induced by Drug |
ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
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ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
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Bone marrow failure | 01.03.03.005 | - | - | |
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