Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propylthiouracil
Drug ID BADD_D01869
Description A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
Indications and Usage Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease).
Marketing Status Prescription; Discontinued
ATC Code H03BA02
DrugBank ID DB00550
KEGG ID D00562
MeSH ID D011441
PubChem ID 657298
TTD Drug ID D00MIN
NDC Product Code 20012-0001; 49452-6112; 65319-1059; 68084-964; 51927-0163; 51927-1183; 59348-0013; 70752-171; 67253-651; 0228-2348
Synonyms Propylthiouracil | 6-Propyl-2-Thiouracil | 6 Propyl 2 Thiouracil
Chemical Information
Molecular Formula C7H10N2OS
CAS Registry Number 51-52-5
SMILES CCCC1=CC(=O)NC(=S)N1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
VasculitisMitochondrial substrate carrier family protein ancAO97470Not Available9181282; 11250767; 8103148; 15746603; 15473130; 15138182; 12507274; 15730621
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Proteinuria20.02.01.0110.010931%
Pruritus23.03.12.001--
Pulmonary alveolar haemorrhage24.07.01.015; 22.01.02.0050.016396%Not Available
Pyrexia08.05.02.0030.010931%
Rash23.03.13.001--Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.005703%
Septic shock24.06.02.011; 11.01.11.0040.002851%Not Available
Skin ulcer24.04.03.007; 23.07.03.003--
Somnolence19.02.05.003; 17.02.04.006--
Splenomegaly01.09.02.001--Not Available
Tachycardia02.03.02.0070.016396%Not Available
Tachypnoea22.02.01.0140.010931%Not Available
Thrombocytopenia01.08.01.002--Not Available
Thyroid disorder05.02.01.0020.010931%Not Available
Thyrotoxic crisis19.07.03.006; 14.11.01.016; 05.02.02.004; 06.09.04.0040.004277%Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vasculitis10.02.02.006; 24.05.02.0010.060119%
Vasculitis necrotising10.02.02.008; 24.05.02.0020.004277%Not Available
Vertigo17.02.12.002; 04.04.01.003--
Vomiting07.01.07.0030.016396%
Lupus-like syndrome10.04.03.003; 23.03.02.004; 15.06.02.004--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Haemorrhage24.07.01.002--Not Available
Antineutrophil cytoplasmic antibody positive13.06.01.0120.021861%Not Available
Salivary gland disorder07.06.02.001--Not Available
Pigmentation disorder23.05.03.001--Not Available
Renal impairment20.01.03.0100.016396%Not Available
Bone marrow failure01.03.03.005--
Liver injury12.01.02.003; 09.01.07.022--Not Available
Organising pneumonia22.01.02.0080.010931%Not Available
The 3th Page    First    Pre   3 4    Next   Last    Total 4 Pages