Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propylthiouracil
Drug ID BADD_D01869
Description A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
Indications and Usage Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease).
Marketing Status Prescription; Discontinued
ATC Code H03BA02
DrugBank ID DB00550
KEGG ID D00562
MeSH ID D011441
PubChem ID 657298
TTD Drug ID D00MIN
NDC Product Code 20012-0001; 49452-6112; 65319-1059; 68084-964; 51927-0163; 51927-1183; 59348-0013; 70752-171; 67253-651; 0228-2348
Synonyms Propylthiouracil | 6-Propyl-2-Thiouracil | 6 Propyl 2 Thiouracil
Chemical Information
Molecular Formula C7H10N2OS
CAS Registry Number 51-52-5
SMILES CCCC1=CC(=O)NC(=S)N1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
VasculitisMitochondrial substrate carrier family protein ancAO97470Not Available9181282; 11250767; 8103148; 15746603; 15473130; 15138182; 12507274; 15730621
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute hepatic failure09.01.03.0010.009980%Not Available
Acute respiratory distress syndrome22.01.03.0010.002851%
Ageusia07.14.03.003; 17.02.07.001--Not Available
Agranulocytosis01.02.03.0010.032792%Not Available
Alopecia23.02.02.001--
Anaemia01.03.02.0010.010931%
Aplasia cutis congenita23.01.04.004; 03.05.01.0110.002851%Not Available
Aplastic anaemia01.03.03.002--Not Available
Arteritis24.05.01.001--Not Available
Arthralgia15.01.02.0010.016396%
Aspartate aminotransferase increased13.03.01.0060.010931%
Asthenia08.01.01.0010.010931%Not Available
Blood bilirubin increased13.03.01.0080.016396%
Body temperature increased13.15.01.001--Not Available
Chills15.05.03.016; 08.01.09.0010.010931%
Cough22.02.03.0010.010931%
Deafness neurosensory17.04.07.001; 04.02.01.0020.010931%Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Disseminated intravascular coagulation24.01.01.010; 01.01.02.0020.002851%
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.0020.016396%
Erythema nodosum23.07.02.001; 10.02.01.020--Not Available
Exomphalos07.16.03.002; 03.04.07.0010.010931%Not Available
Fatigue08.01.01.0020.021861%
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.0010.002851%Not Available
Glomerulonephritis10.02.01.006; 20.05.01.0010.010931%Not Available
Glomerulonephritis rapidly progressive20.05.01.004; 10.04.04.0080.005703%Not Available
Granulocytopenia01.02.03.003--Not Available
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