Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propranolol
Drug ID BADD_D01867
Description Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.[L6904] Propranolol is used to treat a number of conditions but most commonly is used for hypertension.[L6901,L6904,L6907] Propranolol was granted FDA approval on 13 November 1967.[L6904]
Indications and Usage For the prophylaxis of migraine.
Marketing Status Prescription; Discontinued
ATC Code C07AA05
DrugBank ID DB00571
KEGG ID D08443
MeSH ID D011433
PubChem ID 4946
TTD Drug ID D04JEE
NDC Product Code Not Available
Synonyms Propranolol | Propanolol | Inderal | Avlocardyl | AY-20694 | AY 20694 | AY20694 | Rexigen | Dexpropranolol | Dociton | Obsidan | Obzidan | Propranolol Hydrochloride | Hydrochloride, Propranolol | Anaprilin | Anapriline | Betadren
Chemical Information
Molecular Formula C16H21NO2
CAS Registry Number 525-66-6
SMILES CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
BradycardiaCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
BradycardiaCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
HypotensionCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
HypotensionCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
Mitochondrial toxicityCa2+/Mg2+ ATPaseQ63080Not Available3157382; 6324685; 2996181; 7994564; 6713449; 10370869; 2938592; 12498738; 2630100; 6316993
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Poisoning and toxicityCytochrome P450 1A1P04798Not Available15094323; 11906967; 15224175
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypoglycaemic coma14.06.03.004; 05.06.03.004; 17.02.09.0050.000380%Not Available
Hypokalaemia14.05.03.0020.000633%
Hypomagnesaemia14.04.02.0010.000253%
Hyponatraemia14.05.04.0020.000633%
Hypotension24.06.03.0020.011394%
Hypothermia12.05.03.001; 08.05.01.0030.002279%
Hypotonia17.05.02.002; 15.05.04.0080.001519%Not Available
Hypoxia22.02.02.0030.001139%
Infection11.01.08.002--Not Available
Influenza like illness08.01.03.010--
Insomnia17.15.03.002; 19.02.01.0020.005697%
Intentional self-injury19.12.01.002; 12.01.08.0360.000760%Not Available
Intestinal ischaemia24.04.08.001; 07.15.02.0010.000231%Not Available
Intestinal obstruction07.13.01.0020.000380%Not Available
Irritability19.04.02.013; 08.01.03.0110.003165%
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.000380%Not Available
Joint dislocation15.01.07.002; 12.04.02.0070.000253%Not Available
Ketoacidosis14.01.01.0080.001013%Not Available
Lacrimation increased06.08.02.0040.000380%
Lactic acidosis14.01.01.002--Not Available
Laryngospasm22.04.02.002--
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.003671%
Lip ulceration07.05.01.0060.000253%Not Available
Livedo reticularis24.03.04.003; 23.06.05.0010.000380%Not Available
Liver function test abnormal13.03.01.013--Not Available
Loss of consciousness17.02.04.0040.002152%Not Available
Lower respiratory tract infection11.01.09.002; 22.07.01.0020.000633%Not Available
Malaise08.01.01.003--
Mania19.16.02.0020.000253%
Memory impairment19.20.01.003; 17.03.02.0030.001139%
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