Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propranolol
Drug ID BADD_D01867
Description Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.[L6904] Propranolol is used to treat a number of conditions but most commonly is used for hypertension.[L6901,L6904,L6907] Propranolol was granted FDA approval on 13 November 1967.[L6904]
Indications and Usage For the prophylaxis of migraine.
Marketing Status Prescription; Discontinued
ATC Code C07AA05
DrugBank ID DB00571
KEGG ID D08443
MeSH ID D011433
PubChem ID 4946
TTD Drug ID D04JEE
NDC Product Code Not Available
Synonyms Propranolol | Propanolol | Inderal | Avlocardyl | AY-20694 | AY 20694 | AY20694 | Rexigen | Dexpropranolol | Dociton | Obsidan | Obzidan | Propranolol Hydrochloride | Hydrochloride, Propranolol | Anaprilin | Anapriline | Betadren
Chemical Information
Molecular Formula C16H21NO2
CAS Registry Number 525-66-6
SMILES CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
BradycardiaCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
BradycardiaCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
HypotensionCytochrome P450 3A4P08684T3784816634720; 7594046; 8245337; 16770596; 10825413; 7694600
HypotensionCytochrome P450 3A4P08684T3784812864757; 15209687; 11999139
Mitochondrial toxicityCa2+/Mg2+ ATPaseQ63080Not Available3157382; 6324685; 2996181; 7994564; 6713449; 10370869; 2938592; 12498738; 2630100; 6316993
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Poisoning and toxicityCytochrome P450 1A1P04798Not Available15094323; 11906967; 15224175
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Arthralgia15.01.02.001--
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.000760%
Aspartate aminotransferase increased13.03.01.006--
Asphyxia12.01.08.011; 22.02.02.0010.000231%Not Available
Aspiration22.02.07.0070.000066%
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.0100.000506%Not Available
Atelectasis22.01.02.0010.000253%
Atrial fibrillation02.03.03.002--
Atrioventricular block02.03.01.0020.000363%Not Available
Atrioventricular block complete02.03.01.0030.000132%
Atrioventricular block first degree02.03.01.0040.001266%
Atrioventricular block second degree02.03.01.0050.000506%
Back pain15.03.04.005--
Blister23.03.01.001; 12.01.06.002--Not Available
Blood bicarbonate decreased13.11.01.0190.000506%
Blood creatine phosphokinase increased13.04.01.0010.000760%
Blood creatinine increased13.13.01.004--
Blood glucose decreased13.02.02.0010.001266%Not Available
Blood lactate dehydrogenase increased13.04.02.0020.000253%
Blood lactic acid increased13.02.01.0150.000633%Not Available
Blood potassium increased13.11.01.0110.000253%Not Available
Blood pressure decreased13.14.03.0020.002659%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood pressure systolic decreased13.14.03.0070.000633%Not Available
Blood thyroid stimulating hormone increased13.10.03.0060.000253%
Body temperature decreased13.15.01.0100.000886%Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.015698%Not Available
Breath holding22.02.01.016; 19.01.01.0020.000253%Not Available
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