Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propranolol
Drug ID BADD_D01867
Description Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.[L6904] Propranolol is used to treat a number of conditions but most commonly is used for hypertension.[L6901,L6904,L6907] Propranolol was granted FDA approval on 13 November 1967.[L6904]
Indications and Usage Propranolol is indicated to treat hypertension.[L6907,L6904] Propranolol is also indicated to treat angina pectoris due to coronary atherosclerosis, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, pheochromocytoma, and proliferating infantile hemangioma.[L6904,L6907]
Marketing Status approved; investigational
ATC Code C07AA05
DrugBank ID DB00571
KEGG ID D08443
MeSH ID D011433
PubChem ID 4946
TTD Drug ID D04JEE
NDC Product Code Not Available
UNII 9Y8NXQ24VQ
Synonyms Propranolol | Propanolol | Inderal | Avlocardyl | AY-20694 | AY 20694 | AY20694 | Rexigen | Dexpropranolol | Dociton | Obsidan | Obzidan | Propranolol Hydrochloride | Hydrochloride, Propranolol | Anaprilin | Anapriline | Betadren
Chemical Information
Molecular Formula C16H21NO2
CAS Registry Number 525-66-6
SMILES CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Atrioventricular block02.03.01.0020.000321%Not Available
Atrioventricular block complete02.03.01.0030.000107%
Atrioventricular block first degree02.03.01.0040.000294%
Atrioventricular block second degree02.03.01.0050.000187%
Blood glucose decreased13.02.02.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.004883%Not Available
Bradypnoea22.02.01.0020.000053%Not Available
Breath holding22.02.01.016; 19.01.01.0020.000208%Not Available
Bronchiolitis22.03.02.004; 11.05.04.008--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm22.03.01.004; 10.01.03.0120.000486%
Bundle branch block02.03.01.0090.000080%Not Available
Bundle branch block right02.03.01.0110.000294%Not Available
Cardiac arrest02.03.04.0010.002404%
Cardiac failure02.05.01.001--
Cardiac failure acute02.05.01.0050.000053%Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.001015%Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.000988%Not Available
Cardiomegaly02.04.02.0010.000080%Not Available
Catatonia19.11.01.001--Not Available
Cerebral thrombosis24.01.04.003; 17.08.01.0060.000053%Not Available
Cerebrovascular disorder24.03.05.002; 17.08.02.0020.000107%Not Available
Chest discomfort08.01.08.019; 02.02.02.009; 22.12.02.0020.000475%Not Available
Cholestasis09.01.01.0010.000134%Not Available
Chromaturia20.02.01.0020.000080%
Circulatory collapse24.06.02.0010.000240%Not Available
Cold sweat23.02.03.002; 08.01.03.0240.000705%Not Available
Colitis ischaemic24.04.08.012; 07.08.01.004--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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