Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propoxyphene
Drug ID BADD_D01865
Description Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the market in Europe and the United States. The drug is often referred to as the general form, "propoxyphene", however only the dextro-isomer (dextropropoxyphene) has any analgesic effect. The levo-isomer appears to exhibit a very limited antitussive effect.
Indications and Usage For the relief of mild to moderate pain
Marketing Status Discontinued
ATC Code N02AC04
DrugBank ID DB00647
KEGG ID D00482
MeSH ID D011431
PubChem ID 10100
TTD Drug ID D0D4PB
NDC Product Code Not Available
Synonyms Dextropropoxyphene | Propoxyphene | D-Propoxyphene | D Propoxyphene | Propoxyphene Hydrochloride | Hydrochloride, Propoxyphene | Propoxyphene Hydrochloride, (R*,R*)-(+-)-Isomer | Propoxyphene Sulfate, (S-(R*,S*))-Isomer | Propoxyphene Hydrochloride, (R-(R*,S*))-Isomer | Propoxyphene Hydrochloride, (S-(R*,R*))-Isomer | Propoxyphene Maleate, (+)-Isomer | Propoxyphene Phosphate, (S-(R*,S*))-Isomer | Darvon | Propoxyphene Hydrochloride, (R-(R*,R*))-Isomer
Chemical Information
Molecular Formula C22H29NO2
CAS Registry Number 469-62-5
SMILES CCC(=O)OC(CC1=CC=CC=C1)(C2=CC=CC=C2)C(C)CN(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Bradycardia02.03.02.002--Not Available
Cardiac arrest02.03.04.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Coma17.02.09.001--Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug ineffective08.06.01.006--Not Available
Drug interaction08.06.03.001--Not Available
Drug withdrawal syndrome19.07.02.011; 08.06.02.004--Not Available
Dysphoria19.04.02.004--Not Available
Dyspnoea22.02.01.004; 02.01.03.002--
Euphoric mood19.04.02.006--
Eye disorder06.08.03.001--Not Available
Eye swelling06.08.03.003--Not Available
Feeling abnormal08.01.09.014--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
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