Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propofol
Drug ID BADD_D01864
Description Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
Indications and Usage Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
Marketing Status approved; investigational; vet_approved
ATC Code N01AX10
DrugBank ID DB00818
KEGG ID D00549
MeSH ID D015742
PubChem ID 4943
TTD Drug ID D0A3HB
NDC Product Code 52133-0023; 66064-1015; 14593-885; 63323-269; 0069-0209; 0069-0234; 23155-345; 25021-608; 65219-800; 70518-3256; 69135-0010; 0641-6195; 44657-0044; 16714-528; 51662-1293; 51662-1470; 72572-601; 0641-6196; 72572-590; 0641-6194; 0069-0248; 58032-2019; 0409-4699; 0409-6010; 0591-2136; 16714-977; 72572-612; 16714-690; 51662-1471; 51504-0003
UNII YI7VU623SF
Synonyms Propofol | 2,6-Diisopropylphenol | 2,6 Diisopropylphenol | 2,6-Bis(1-methylethyl)phenol | Disoprofol | Diprivan | Disoprivan | Fresofol | ICI-35,868 | ICI 35,868 | ICI35,868 | ICI-35868 | ICI 35868 | ICI35868 | Ivofol | Propofol Fresenius | Propofol MCT | Propofol Rovi | Propofol-Lipuro | Recofol | Aquafol | Propofol Abbott
Chemical Information
Molecular Formula C12H18O
CAS Registry Number 2078-54-8
SMILES CC(C)C1=C(C(=CC=C1)C(C)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rash23.03.13.001--Not Available
Rash erythematous23.03.13.0290.000447%Not Available
Rash morbilliform23.03.13.0050.000179%Not Available
Rash papular23.03.13.0170.000179%Not Available
Renal failure20.01.03.0050.001429%Not Available
Renal tubular necrosis20.01.07.0030.000179%Not Available
Respiratory acidosis14.01.04.002; 22.02.02.0040.000179%Not Available
Respiratory arrest22.02.01.0090.001876%Not Available
Respiratory depression22.02.01.010; 17.02.05.0470.003305%Not Available
Respiratory disorder22.02.07.0020.000179%Not Available
Respiratory distress22.02.01.0120.000268%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.001697%
Retching07.01.07.0020.000357%Not Available
Rhabdomyolysis15.05.05.0020.004287%
Right ventricular failure02.05.03.002--Not Available
Salivary hypersecretion07.06.01.0090.001554%Not Available
Screaming19.04.02.020; 08.01.03.0990.000357%Not Available
Sedation17.02.04.0050.000572%Not Available
Seizure17.12.03.0010.002697%
Sepsis11.01.11.003--
Serotonin syndrome15.05.04.016; 17.05.02.004; 12.03.01.0410.000268%Not Available
Shock24.06.02.0020.001822%Not Available
Sinus arrest02.03.03.0070.000179%Not Available
Sinus bradycardia02.03.03.0090.000447%
Sinus tachycardia02.03.03.0100.000447%
Skin discolouration23.03.03.0050.000268%Not Available
Skin disorder23.03.03.0070.000179%Not Available
Skin necrosis23.03.03.0110.000179%Not Available
Sleep apnoea syndrome22.02.01.013; 19.02.05.002; 17.15.05.0010.001161%
Sneezing22.12.03.024--
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