Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Propofol
Drug ID BADD_D01864
Description Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
Indications and Usage Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
Marketing Status approved; investigational; vet_approved
ATC Code N01AX10
DrugBank ID DB00818
KEGG ID D00549
MeSH ID D015742
PubChem ID 4943
TTD Drug ID D0A3HB
NDC Product Code 52133-0023; 66064-1015; 14593-885; 63323-269; 0069-0209; 0069-0234; 23155-345; 25021-608; 65219-800; 70518-3256; 69135-0010; 0641-6195; 44657-0044; 16714-528; 51662-1293; 51662-1470; 72572-601; 0641-6196; 72572-590; 0641-6194; 0069-0248; 58032-2019; 0409-4699; 0409-6010; 0591-2136; 16714-977; 72572-612; 16714-690; 51662-1471; 51504-0003
UNII YI7VU623SF
Synonyms Propofol | 2,6-Diisopropylphenol | 2,6 Diisopropylphenol | 2,6-Bis(1-methylethyl)phenol | Disoprofol | Diprivan | Disoprivan | Fresofol | ICI-35,868 | ICI 35,868 | ICI35,868 | ICI-35868 | ICI 35868 | ICI35868 | Ivofol | Propofol Fresenius | Propofol MCT | Propofol Rovi | Propofol-Lipuro | Recofol | Aquafol | Propofol Abbott
Chemical Information
Molecular Formula C12H18O
CAS Registry Number 2078-54-8
SMILES CC(C)C1=C(C(=CC=C1)C(C)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Insomnia19.02.01.002; 17.15.03.002--
Intracranial pressure increased17.07.02.002--Not Available
Lactic acidosis14.01.01.0020.001429%Not Available
Laryngeal oedema23.04.01.005; 10.01.05.003; 22.04.02.0010.000357%
Laryngospasm22.04.02.0020.000982%
Leukocytosis01.02.01.002--
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.0050.000357%Not Available
Loss of consciousness17.02.04.004--Not Available
Mental disability26.01.01.001--Not Available
Metabolic acidosis14.01.01.0030.002929%Not Available
Moaning08.01.03.094; 19.04.02.011--Not Available
Mood swings19.04.03.001--Not Available
Movement disorder17.01.02.0100.001000%Not Available
Muscle contractions involuntary17.05.03.001; 15.05.03.0080.000179%Not Available
Muscle rigidity17.05.02.005; 15.05.04.0010.001322%Not Available
Muscle spasms15.05.03.004--
Muscle twitching15.05.03.0050.000661%Not Available
Myalgia15.05.02.001--
Mydriasis17.02.11.003; 06.05.03.0040.000357%Not Available
Myocardial infarction24.04.04.009; 02.02.02.007--
Myocardial ischaemia24.04.04.010; 02.02.02.0080.000357%Not Available
Myoclonus17.02.05.0080.001804%Not Available
Myoglobinuria20.02.01.010; 15.05.03.009; 02.04.02.0060.000179%Not Available
Myopathy15.05.05.0010.000357%Not Available
Nausea07.01.07.001--
Neonatal disorder18.04.01.001--Not Available
Nervous system disorder17.02.10.0010.000268%Not Available
Neuroleptic malignant syndrome17.05.02.003; 15.05.04.015; 12.03.01.003; 08.05.01.0050.000179%Not Available
Neuromuscular blockade17.05.04.0030.000179%Not Available
Neuropathy peripheral17.09.03.003--Not Available
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