Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propofol
Drug ID BADD_D01864
Description Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
Indications and Usage Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
Marketing Status Prescription; Discontinued
ATC Code N01AX10
DrugBank ID DB00818
KEGG ID D00549
MeSH ID D015742
PubChem ID 4943
TTD Drug ID D0A3HB
NDC Product Code 72572-612; 69135-0010; 52584-699; 0409-4699; 50090-4569; 0641-6194; 25021-608; 63323-269; 0069-0209; 0069-0234; 51504-0003; 58032-2019; 51662-1470; 14593-885; 51662-1471; 72572-583; 44657-0044; 70518-3256; 0591-2136; 72572-590; 0641-6195; 0641-6196; 72572-585; 72572-601; 51662-1293; 18124-027; 65219-427; 0069-0248; 65219-800; 23155-345; 72572-584; 0404-9943; 66064-1015; 52133-0023; 52584-098
Synonyms Propofol | 2,6-Diisopropylphenol | 2,6 Diisopropylphenol | 2,6-Bis(1-methylethyl)phenol | Disoprofol | Diprivan | Disoprivan | Fresofol | ICI-35,868 | ICI 35,868 | ICI35,868 | ICI-35868 | ICI 35868 | ICI35868 | Ivofol | Propofol Fresenius | Propofol MCT | Propofol Rovi | Propofol-Lipuro | Recofol | Aquafol | Propofol Abbott
Chemical Information
Molecular Formula C12H18O
CAS Registry Number 2078-54-8
SMILES CC(C)C1=C(C(=CC=C1)C(C)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pulmonary function test decreased13.19.01.001--Not Available
Hyperlipidaemia14.08.03.001--
Unevaluable event08.01.03.051--Not Available
Increased upper airway secretion22.02.05.0210.000788%Not Available
Procedural pain12.02.05.007; 08.01.08.0090.002364%Not Available
Infusion site urticaria08.02.05.021; 23.04.02.010; 12.07.05.021; 10.01.06.010--Not Available
Weaning failure12.02.07.010--Not Available
Regurgitation07.01.07.0040.000788%Not Available
Upper airway obstruction22.02.05.029--Not Available
Brain injury19.07.03.007; 17.11.01.0030.000206%Not Available
Acute kidney injury20.01.03.0160.010246%
Hypoxic-ischaemic encephalopathy24.04.06.021; 22.02.02.011; 17.13.02.0060.000206%Not Available
Drug-induced liver injury12.03.01.044; 09.01.07.0230.001970%Not Available
Drug effect variable08.06.01.027--Not Available
Multiple organ dysfunction syndrome08.01.03.0570.001850%
Posturing19.11.03.008; 17.01.02.0240.001576%Not Available
Multi-organ disorder08.01.03.0740.000206%Not Available
Troponin T increased13.04.01.0150.000788%
Heart injury12.01.11.003; 02.01.01.0100.001182%Not Available
Klebsiella infection11.02.03.0030.000788%Not Available
Propofol infusion syndrome20.01.03.023; 02.05.01.014; 14.01.01.0150.008019%Not Available
Tryptase increased13.06.03.0130.000788%Not Available
Accidental death12.01.08.040; 08.04.01.0130.000308%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.0120.001576%Not Available
Visceral congestion24.03.02.0330.000206%Not Available
Seizure like phenomena17.12.03.0300.001182%Not Available
Suspected transmission of an infectious agent via product27.02.01.003; 11.07.02.0070.001182%Not Available
The 12th Page    First    Pre   12    Total 12 Pages