Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Holmes-Adie pupil
ADR ID BADD_A10047
ADR Hierarchy
06      Eye disorders
06.05      Ocular neuromuscular disorders
06.05.03      Pupil disorders
06.05.03.014      Holmes-Adie pupil
17      Nervous system disorders
17.02      Neurological disorders NEC
17.02.11      Pupillary signs
17.02.11.010      Holmes-Adie pupil
Description A syndrome characterized by a TONIC PUPIL that occurs in combination with decreased lower extremity reflexes. The affected pupil will respond more briskly to accommodation than to light (light-near dissociation) and is supersensitive to dilute pilocarpine eye drops, which induce pupillary constriction. Pathologic features include degeneration of the ciliary ganglion and postganglionic parasympathetic fibers that innervate the pupillary constrictor muscle. (From Adams et al., Principles of Neurology, 6th ed, p279) [MeSH]
MedDRA Code 10020352
MeSH ID D000270
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Holmes-Adie pupil | Holmes-Adie syndrome | Pupil Adie's | Adie Syndrome | Syndrome, Adie | Holmes-Adie Syndrome | Holmes Adie Syndrome | Syndrome, Holmes-Adie | Poorly Reacting Pupils | Poorly Reacting Pupil | Pupil, Poorly Reacting | Pupils, Poorly Reacting | Adie's Syndrome | Syndrome, Adie's
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01864Propofol0.000179%
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