Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propantheline bromide
Drug ID BADD_D01861
Description A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.
Indications and Usage For the treatment of enuresis. It has also been used for hyperhidrosis, and cramps or spasms of the stomach, intestines or bladder.
Marketing Status Prescription; Discontinued
ATC Code A03AB05
DrugBank ID DB00782
KEGG ID D00481
MeSH ID D011413
PubChem ID 9279
TTD Drug ID D0V5ZZ
NDC Product Code 0054-4721; 58159-065
Synonyms Propantheline | Propantheline Bromide | Bromide, Propantheline | Probanthine | Pro-Banthine | Pro Banthine
Chemical Information
Molecular Formula C23H30NO3.Br
CAS Registry Number 50-34-0
SMILES CC(C)[N+](C)(CCOC(=O)C1C2=CC=CC=C2OC3=CC=CC=C13)C(C)C.[Br-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Ageusia17.02.07.001; 07.14.03.003--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Asthenia08.01.01.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cycloplegia17.17.02.003; 06.05.03.002--Not Available
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Insomnia19.02.01.002; 17.15.03.002--
Intraocular pressure increased13.07.04.002--Not Available
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Palpitations02.01.02.003--
Somnolence19.02.05.003; 17.02.04.006--
Suppressed lactation18.06.02.001; 21.05.02.003--Not Available
Tachycardia02.03.02.007--Not Available
Urinary hesitation20.02.02.009--Not Available
Urinary retention20.02.02.011--
Urticaria23.04.02.001; 10.01.06.001--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Erectile dysfunction21.03.01.007; 19.08.04.001--
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