Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propafenone
Drug ID BADD_D01856
Description An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Indications and Usage Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.
Marketing Status Prescription; Discontinued
ATC Code C01BC03
DrugBank ID DB01182
KEGG ID D08435
MeSH ID D011405
PubChem ID 4932
TTD Drug ID D0J2KV
NDC Product Code 51407-477; 51407-479; 24979-087; 71205-940; 12598-6285; 51407-478; 24979-085; 69680-130; 71205-941; 69680-132; 69680-131; 71205-942; 24979-086
Synonyms Propafenone | Propafenone Hydrochloride, (R)-Isomer | Rytmo-Puren | Rytmogenat | SA-79 | SA 79 | SA79 | Propafenone, (+-)-Isomer | Propafenone, (R)-Isomer | Propafenone, (S)-Isomer | Propamerck | Apo-Propafenone | Baxarytmon | Cuxafenon | Fenoprain | Jutanorm | Nistaken | Prolecofen | Propafenon AL | Propafenon Hexal | Propafenone Hydrochloride | Hydrochloride, Propafenone | Propafenone Hydrochloride, (S)-Isomer | Rythmol | Propafenon Minden | Norfenon | Pintoform | Rytmonorm | Arythmol
Chemical Information
Molecular Formula C21H27NO3
CAS Registry Number 54063-53-5
SMILES CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Presyncope24.06.02.010; 17.02.05.009; 02.01.02.0070.003832%
Prostatic specific antigen increased13.22.01.001--Not Available
Prostatism21.04.01.003; 20.02.03.009--Not Available
Proteinuria20.02.01.011--
Prothrombin level decreased13.01.02.010--Not Available
Prothrombin level increased13.01.02.011--Not Available
Pruritus23.03.12.001--
Pulmonary congestion24.03.08.001; 22.01.03.002; 02.05.02.002--Not Available
Pulse abnormal13.14.04.004--Not Available
Pupillary light reflex tests abnormal13.07.04.0030.001916%Not Available
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Pyrexia08.05.02.003--
Pyuria20.02.01.012; 11.01.08.043--Not Available
Rales22.02.04.004--Not Available
Rash23.03.13.001--Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Red blood cell count decreased13.01.05.007--Not Available
Renal failure20.01.03.005--Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.001916%
Retinal disorder06.08.03.005--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Rhythm idioventricular02.03.04.0190.003832%Not Available
Sciatica17.10.03.001; 15.10.01.001--Not Available
Seizure17.12.03.0010.012453%
Sensory loss17.02.07.007--Not Available
Shock24.06.02.0020.004790%Not Available
Sinoatrial block02.03.01.010--Not Available
Sinus arrest02.03.03.007--Not Available
Sinus arrhythmia02.03.03.0080.001916%Not Available
Sinus bradycardia02.03.03.0090.003832%
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