Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Propafenone
Drug ID BADD_D01856
Description An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Indications and Usage Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia.
Marketing Status approved
ATC Code C01BC03
DrugBank ID DB01182
KEGG ID D08435
MeSH ID D011405
PubChem ID 4932
TTD Drug ID D0J2KV
NDC Product Code 51407-478; 24979-086; 69680-130; 69680-131; 71205-942; 12598-6285; 71205-941; 24979-087; 24979-085; 51407-477; 71205-940; 69680-132; 51407-479
UNII 68IQX3T69U
Synonyms Propafenone | Propafenone Hydrochloride, (R)-Isomer | Rytmo-Puren | Rytmogenat | SA-79 | SA 79 | SA79 | Propafenone, (+-)-Isomer | Propafenone, (R)-Isomer | Propafenone, (S)-Isomer | Propamerck | Apo-Propafenone | Baxarytmon | Cuxafenon | Fenoprain | Jutanorm | Nistaken | Prolecofen | Propafenon AL | Propafenon Hexal | Propafenone Hydrochloride | Hydrochloride, Propafenone | Propafenone Hydrochloride, (S)-Isomer | Rythmol | Propafenon Minden | Norfenon | Pintoform | Rytmonorm | Arythmol
Chemical Information
Molecular Formula C21H27NO3
CAS Registry Number 54063-53-5
SMILES CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dry skin23.03.03.001--
Dry throat22.12.03.005; 07.06.01.005--Not Available
Duodenitis07.08.03.001--Not Available
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dyspnoea02.11.05.003; 22.02.01.0040.002466%
Dysuria20.02.02.002--
Ear disorder04.03.01.001--Not Available
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Electrocardiogram abnormal13.14.05.001--Not Available
Electrocardiogram QRS complex13.14.05.034--Not Available
Electrocardiogram QT prolonged13.14.05.004--
Emotional disorder19.04.02.005--Not Available
Endophthalmitis11.01.06.003; 06.04.05.009--
Eosinophil count increased13.01.06.004--Not Available
Eosinophilia01.02.04.0010.000418%
Epistaxis22.04.03.001; 24.07.01.005--
Eructation07.01.02.003--
Erythema23.03.06.001--Not Available
Extrasystoles02.03.02.003--Not Available
Eye disorder06.08.03.001--Not Available
Eye haemorrhage12.02.02.012; 24.07.05.002; 06.07.02.001--Not Available
Eye inflammation06.04.05.002--Not Available
Eye irritation06.04.05.003--Not Available
Eyelid ptosis17.17.02.004; 06.05.01.002--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Feeling hot08.01.09.009--Not Available
Flatulence07.01.04.002--
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ADReCS-Target
Drug Name ADR Term Target
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